Diazoxide, a K Channel Opener, Prevents Ischemia–Reperfusion Injury in Rodent Pancreatic Islets

Diazoxide, a K Channel Opener, Prevents Ischemia–Reperfusion Injury in Rodent Pancreatic Islets

Diazoxide (DZ) is a pharmacological opener of ATP-sensitive K + channels that has been used for mimicking ischemic preconditioning and shows protection against ischemic damage. Here we investigated whether diazoxide supplementation to University of Wisconsin (UW) solution has cellular protection dur...

Full description

Bibliographic Details
Main Authors:	Yong Wang, Shusen Wang, Tricia Harvat, Katie Kinzer, Lisa Zhang, Feng Feng, Meirigeng Qi, Jose Oberholzer
Format:	Article
Language:	English
Published:	SAGE Publishing 2015-01-01
Series:	Cell Transplantation
Online Access:	https://doi.org/10.3727/096368913X673441

Similar Items

Highly Purified versus Filtered Crude Collagenase: Comparable Human Islet Isolation Outcomes
by: Yong Wang, et al.
Published: (2011-12-01)

The Effect of Diazoxide on Ultrastructural Changes Following Ischemia-Reperfusion Injury of Rat Brain
by: Mehdi Mehdizadeh, et al.
Published: (2010-05-01)

The Effect of Diazoxide on Ultrastructural Changes Following Ischemia-Reperfusion Injury of Rat Brain
by: Mehdi Mehdizadeh, et al.
Published: (2010-05-01)

Histidine-Tryptophan-Ketoglutarate and University of Wisconsin Solution Demonstrate Equal Effectiveness in the Preservation of Human Pancreata Intended for Islet Isolation: A Large-Scale, Single-Center Experience
by: Daniel H. Paushter, et al.
Published: (2013-07-01)

Transplantation of Encapsulated Pancreatic Islets as a Treatment for Patients with Type 1 Diabetes Mellitus
by: Meirigeng Qi
Published: (2014-01-01)

Implication of Mitochondrial Cytoprotection in Human Islet Isolation and Transplantation
by: Yong Wang, et al.
Published: (2012-01-01)

Effects of diazoxide in experimental acute necrotizing pancreatitis
by: Roberta de Oliveira Andrade, et al.

Distinct effect of diazoxide on insul in secretion stimulated by protein kinase A and protein kinase C in rat pancreatic islets
by: Shen, Zhen-ping
Published: (2011)

Phycocyanin/PEG-b-(PG-g-PEI) attenuated hepatic ischemia/reperfusion-induced pancreatic islet injury and enlarged islet functionality
by: Tong F, et al.
Published: (2019-01-01)

Diazoxide Protects against Myocardial Ischemia/Reperfusion Injury by Moderating ERS via Regulation of the miR-10a/IRE1 Pathway
by: Lin Zhang, et al.
Published: (2020-01-01)

Effect of Diazoxide on Ultra-structure morphology of Rat parietal cortex after ischemic – reperfusion
by: Katebi M (PhD), et al.
Published: (2010-06-01)

Robot-assisted pancreatoduodenectomy with preservation of the vascular supply for autologous islet cell isolation and transplantation: a case report
by: Giulianotti Piero, et al.
Published: (2012-03-01)

Pancreatic Islets Accumulate Cadmium in a Rodent Model of Cadmium-Induced Hyperglycemia
by: Ryan Fitzgerald, et al.
Published: (2021-12-01)

Genes Induced by Panax Notoginseng in a Rodent Model of Ischemia-Reperfusion Injury
by: Lanqing Meng, et al.
Published: (2020-01-01)

Diazoxide affects mitochondrial bioenergetics by the opening of mKATP channel on submicromolar scale
by: Olga Akopova, et al.
Published: (2020-04-01)

Optic Nerve Degeneration after Retinal Ischemia/Reperfusion in a Rodent Model
by: Marina Renner, et al.
Published: (2017-08-01)

Evaluation of Neuroprotective Effect of Thymoquinone Nanoformulation in the Rodent Cerebral Ischemia-Reperfusion Model
by: Xiao-Yu Xiao, et al.
Published: (2016-01-01)

Use of diazoxide in hypoglycemia with hyperinsulinemia in hemodialysis
by: Maria Dolores Arenas Jiménez, et al.
Published: (2018-03-01)

Effects of diazoxide on rat isolated atria
by: Nikoui V, et al.
Published: (2012-11-01)

Islet transplantation in rodents: do encapsulated islets really work?
by: Yngrid Ellyn Dias Maciel de Souza, et al.
Published: (2011-06-01)

ISCHEMIA/REPERFUSION EFFECT ON PANCREATIC VOLUMETRICAL BLOOD FLOW VELOCITY
by: Dmytry Kolmykov, et al.
Published: (2015-12-01)

Gender difference and sex hormone production in rodent renal ischemia reperfusion injury and repair
by: Ghazali Daniel, et al.
Published: (2011-06-01)

Central Necrosis in Isolated Hypoxic Human Pancreatic Islets: Evidence for Postisolation Ischemia
by: Mauro Giuliani, et al.
Published: (2005-01-01)

Systematic Analysis of Donor and Isolation Factor's Impact on Human Islet Yield and Size Distribution
by: Y. Wang, et al.
Published: (2013-12-01)

Unsuccessful Desensitization in a Child with Hypersensitivity to Diazoxide
by: Francesca Mori, et al.
Published: (2017-10-01)

Stability of Diazoxide in Extemporaneously Compounded Oral Suspensions.
by: Mihaela Friciu, et al.
Published: (2016-01-01)

Reversible Pulmonary Hypertension in an Infant Treated with Diazoxide
by: Masoud Dehdashtian
Published: (2014-06-01)

The danger of diazoxide in the neonatal intensive care unit
by: Jay Desai, et al.
Published: (2021-05-01)

Circular RNA Microarray Analyses in Hepatic Ischemia-Reperfusion Injury With Ischemic Preconditioning Prevention
by: Xinyao Tian, et al.
Published: (2021-03-01)

The Effects of Two Anesthetics, Propofol and Sevoflurane, on Liver Ischemia/Reperfusion Injury
by: Zhijie Xu, et al.
Published: (2016-04-01)

Successful medical management of insulinoma with diazoxide for 27 years
by: Annabelle M Warren, et al.
Published: (2020-10-01)

Diazoxide-responsive hyperinsulinaemic hypoglycaemia in tyrosinaemia type 1
by: Ellada Sotiridou, et al.
Published: (2021-01-01)

Diazoxide promotes oligodendrocyte precursor cell proliferation and myelination.
by: Birgit Fogal, et al.
Published: (2010-05-01)

Pharmacological Preconditioning Using Diazoxide Regulates Store-Operated Ca2 + Channels in Adult Rat Cardiomyocytes
by: Raúl Sampieri, et al.
Published: (2020-01-01)

Noninvasive Assessment of Fibrosis Following Ischemia/Reperfusion Injury in Rodents Utilizing Na Magnetic Resonance Imaging
by: Per Mose Nielsen, et al.
Published: (2020-08-01)

Variations in Rodent Models of Type 1 Diabetes: Islet Morphology
by: Lesya Novikova, et al.
Published: (2013-01-01)

Pancreatic islet transplantation
by: Corrêa-Giannella Maria, et al.
Published: (2009-09-01)

Pancreatic islet transplantation.
by: Mark A Naftanel, et al.
Published: (2004-12-01)

Obestatin Accelerates the Recovery in the Course of Ischemia/Reperfusion-Induced Acute Pancreatitis in Rats.
by: Jakub Bukowczan, et al.
Published: (2015-01-01)

Pretreatment with Warfarin Attenuates the Development of Ischemia/Reperfusion-Induced Acute Pancreatitis in Rats
by: Dawid Maduzia, et al.
Published: (2020-05-01)