A Small Molecule BH3-mimetic Suppresses Cigarette Smoke-Induced Mucous Expression in Airway Epithelial Cells

A Small Molecule BH3-mimetic Suppresses Cigarette Smoke-Induced Mucous Expression in Airway Epithelial Cells

Abstract Cigarette smoke (CS) exposure is one of the primary risk factors associated with the chronic mucous hypersecretion (CMH). The antiapoptotic protein, Bcl-2 sustains hyperplastic mucous cells, and the airway epithelium of ex-smokers with CMH as well as mice exposed to chronic CS showed increa...

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Bibliographic Details
Main Authors: Shah S. Hussain, Shebin George, Shashi Singh, Rahul Jayant, Chien-An Hu, Mohan Sopori, Hitendra S. Chand
Format: Article
Language:English
Published: Nature Publishing Group 2018-09-01
Series:Scientific Reports
Subjects:
Airway Epithelial Cells (AECs)
MUC1 Expression
Epithelial Growth Factor Receptor (EGFR)
Extracellular-signal Regulating Kinase 1/2 (ERK1/2)
Human AECs
Online Access:https://doi.org/10.1038/s41598-018-32114-w

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