Malathion induced testicular toxicity and oxidative damage in male mice: the protective effect of curcumin

Abstract Background The organophosphorus (OP) pesticide malathion is a highly neurotoxic compound, leading to cholinergic syndrome. Malathion produces reproductive toxicity. Objectives To investigate the protective effects of curcumin on the testicular toxicity induced in male mice orally administra...

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Main Authors: Rehab Ibrahim Ali, Mahrous Abdelbasset Ibrahim
Format: Article
Language:English
Published: SpringerOpen 2018-12-01
Series:Egyptian Journal of Forensic Sciences
Subjects:
Online Access:http://link.springer.com/article/10.1186/s41935-018-0099-x
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spelling doaj-117ec08803964dc3a947e4cb1c08e9532020-11-25T00:39:07ZengSpringerOpenEgyptian Journal of Forensic Sciences2090-59392018-12-018111310.1186/s41935-018-0099-xMalathion induced testicular toxicity and oxidative damage in male mice: the protective effect of curcuminRehab Ibrahim Ali0Mahrous Abdelbasset Ibrahim1Pathology Department, College of Medicine, Jouf UniversityForensic Medicine and Clinical Toxicology Department, College of Medicine, Jouf UniversityAbstract Background The organophosphorus (OP) pesticide malathion is a highly neurotoxic compound, leading to cholinergic syndrome. Malathion produces reproductive toxicity. Objectives To investigate the protective effects of curcumin on the testicular toxicity induced in male mice orally administrated with malathion. Materials and methods Forty-eight mature male mice were used. The mice were divided into four groups, 12 mice each, and treated for 4 weeks as follows: the control (G1), curcumin-treated group (G2), malathion-treated group (G3), and the curcumin plus malathion-treated group (G4). At the end of the experiment, the mice were sacrificed and dissected, and tissue samples were obtained and antioxidant parameters were examined. Tissue samples were also histopathologicaly and immunohistochemically assessed. Samples of blood were collected for assessing the levels of serum hormones, namely follicle-stimulating hormone (FSH), luteinizing hormone (LH), testosterone, and acetylcholinesterase activity (AChE). Results Malathion exposure caused a decrease in serum testosterone and LH levels and antioxidant enzymes (SOD and CAT) and elevation of oxidative stress marker (MDA). Histological changes were as well observed in the form of maturation abnormalities, intratubular necrosis, and inflammatory infiltrate in malathion-treated mice. Co-administration of curcumin with malathion reduced lipid peroxidation (LPO) activity and improved spermatogenesis and increased catalase (CAT), superoxide dismutase (SOD), and testosterone levels. Conclusion The current study showed that curcumin could ameliorate the elevated concentration of lipid peroxidation products, increase the levels of antioxidative markers, and improve the pathological changes in the testis induced by malathion administration. The capacity of curcumin to work as antioxidant supposedly relates to its structure.http://link.springer.com/article/10.1186/s41935-018-0099-xMalathionToxicityCurcuminOxidative stressTestis
collection DOAJ
language English
format Article
sources DOAJ
author Rehab Ibrahim Ali
Mahrous Abdelbasset Ibrahim
spellingShingle Rehab Ibrahim Ali
Mahrous Abdelbasset Ibrahim
Malathion induced testicular toxicity and oxidative damage in male mice: the protective effect of curcumin
Egyptian Journal of Forensic Sciences
Malathion
Toxicity
Curcumin
Oxidative stress
Testis
author_facet Rehab Ibrahim Ali
Mahrous Abdelbasset Ibrahim
author_sort Rehab Ibrahim Ali
title Malathion induced testicular toxicity and oxidative damage in male mice: the protective effect of curcumin
title_short Malathion induced testicular toxicity and oxidative damage in male mice: the protective effect of curcumin
title_full Malathion induced testicular toxicity and oxidative damage in male mice: the protective effect of curcumin
title_fullStr Malathion induced testicular toxicity and oxidative damage in male mice: the protective effect of curcumin
title_full_unstemmed Malathion induced testicular toxicity and oxidative damage in male mice: the protective effect of curcumin
title_sort malathion induced testicular toxicity and oxidative damage in male mice: the protective effect of curcumin
publisher SpringerOpen
series Egyptian Journal of Forensic Sciences
issn 2090-5939
publishDate 2018-12-01
description Abstract Background The organophosphorus (OP) pesticide malathion is a highly neurotoxic compound, leading to cholinergic syndrome. Malathion produces reproductive toxicity. Objectives To investigate the protective effects of curcumin on the testicular toxicity induced in male mice orally administrated with malathion. Materials and methods Forty-eight mature male mice were used. The mice were divided into four groups, 12 mice each, and treated for 4 weeks as follows: the control (G1), curcumin-treated group (G2), malathion-treated group (G3), and the curcumin plus malathion-treated group (G4). At the end of the experiment, the mice were sacrificed and dissected, and tissue samples were obtained and antioxidant parameters were examined. Tissue samples were also histopathologicaly and immunohistochemically assessed. Samples of blood were collected for assessing the levels of serum hormones, namely follicle-stimulating hormone (FSH), luteinizing hormone (LH), testosterone, and acetylcholinesterase activity (AChE). Results Malathion exposure caused a decrease in serum testosterone and LH levels and antioxidant enzymes (SOD and CAT) and elevation of oxidative stress marker (MDA). Histological changes were as well observed in the form of maturation abnormalities, intratubular necrosis, and inflammatory infiltrate in malathion-treated mice. Co-administration of curcumin with malathion reduced lipid peroxidation (LPO) activity and improved spermatogenesis and increased catalase (CAT), superoxide dismutase (SOD), and testosterone levels. Conclusion The current study showed that curcumin could ameliorate the elevated concentration of lipid peroxidation products, increase the levels of antioxidative markers, and improve the pathological changes in the testis induced by malathion administration. The capacity of curcumin to work as antioxidant supposedly relates to its structure.
topic Malathion
Toxicity
Curcumin
Oxidative stress
Testis
url http://link.springer.com/article/10.1186/s41935-018-0099-x
work_keys_str_mv AT rehabibrahimali malathioninducedtesticulartoxicityandoxidativedamageinmalemicetheprotectiveeffectofcurcumin
AT mahrousabdelbassetibrahim malathioninducedtesticulartoxicityandoxidativedamageinmalemicetheprotectiveeffectofcurcumin
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