Absorption mechanism of three curcumin constituents through in situ intestinal perfusion method

This study aimed to investigate the absorption mechanism of three curcumin constituents in rat small intestines. Self-emulsification was used to solubilize the three curcumin constituents, and the rat in situ intestinal perfusion method was used to study factors on drug absorption, including drug ma...

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Main Authors:	Y.-H. Wang, X.-M. Ke, C.-H. Zhang, R.-P. Yang
Format:	Article
Language:	English
Published:	Associação Brasileira de Divulgação Científica 2017-09-01
Series:	Brazilian Journal of Medical and Biological Research
Subjects:	Curcumin Demethoxycurcumin Bisdethoxycurcumin In situ intestinal perfusion Absorption mechanism
Online Access:	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2017001100612&lng=en&tlng=en

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record_format	Article
spelling	doaj-117c1803b1584b7284cc56602dde52282020-11-24T22:41:41ZengAssociação Brasileira de Divulgação CientíficaBrazilian Journal of Medical and Biological Research1414-431X2017-09-01501110.1590/1414-431x20176353S0100-879X2017001100612Absorption mechanism of three curcumin constituents through in situ intestinal perfusion methodY.-H. WangX.-M. KeC.-H. ZhangR.-P. YangThis study aimed to investigate the absorption mechanism of three curcumin constituents in rat small intestines. Self-emulsification was used to solubilize the three curcumin constituents, and the rat in situ intestinal perfusion method was used to study factors on drug absorption, including drug mass concentration, absorption site, and the different types and concentrations of absorption inhibitors. Within the scope of experimental concentrations, three curcumin constituents were absorbed in rat small intestines through the active transport mechanism.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2017001100612&lng=en&tlng=enCurcuminDemethoxycurcuminBisdethoxycurcuminIn situ intestinal perfusionAbsorption mechanism
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Y.-H. Wang X.-M. Ke C.-H. Zhang R.-P. Yang
spellingShingle	Y.-H. Wang X.-M. Ke C.-H. Zhang R.-P. Yang Absorption mechanism of three curcumin constituents through in situ intestinal perfusion method Brazilian Journal of Medical and Biological Research Curcumin Demethoxycurcumin Bisdethoxycurcumin In situ intestinal perfusion Absorption mechanism
author_facet	Y.-H. Wang X.-M. Ke C.-H. Zhang R.-P. Yang
author_sort	Y.-H. Wang
title	Absorption mechanism of three curcumin constituents through in situ intestinal perfusion method
title_short	Absorption mechanism of three curcumin constituents through in situ intestinal perfusion method
title_full	Absorption mechanism of three curcumin constituents through in situ intestinal perfusion method
title_fullStr	Absorption mechanism of three curcumin constituents through in situ intestinal perfusion method
title_full_unstemmed	Absorption mechanism of three curcumin constituents through in situ intestinal perfusion method
title_sort	absorption mechanism of three curcumin constituents through in situ intestinal perfusion method
publisher	Associação Brasileira de Divulgação Científica
series	Brazilian Journal of Medical and Biological Research
issn	1414-431X
publishDate	2017-09-01
description	This study aimed to investigate the absorption mechanism of three curcumin constituents in rat small intestines. Self-emulsification was used to solubilize the three curcumin constituents, and the rat in situ intestinal perfusion method was used to study factors on drug absorption, including drug mass concentration, absorption site, and the different types and concentrations of absorption inhibitors. Within the scope of experimental concentrations, three curcumin constituents were absorbed in rat small intestines through the active transport mechanism.
topic	Curcumin Demethoxycurcumin Bisdethoxycurcumin In situ intestinal perfusion Absorption mechanism
url	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2017001100612&lng=en&tlng=en
work_keys_str_mv	AT yhwang absorptionmechanismofthreecurcuminconstituentsthroughinsituintestinalperfusionmethod AT xmke absorptionmechanismofthreecurcuminconstituentsthroughinsituintestinalperfusionmethod AT chzhang absorptionmechanismofthreecurcuminconstituentsthroughinsituintestinalperfusionmethod AT rpyang absorptionmechanismofthreecurcuminconstituentsthroughinsituintestinalperfusionmethod
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Absorption mechanism of three curcumin constituents through in situ intestinal perfusion method

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