Two independent positive feedbacks and bistability in the Bcl-2 apoptotic switch.

Two independent positive feedbacks and bistability in the Bcl-2 apoptotic switch.

<h4>Background</h4>The complex interplay between B-cell lymphoma 2 (Bcl-2) family proteins constitutes a crucial checkpoint in apoptosis. Its detailed molecular mechanism remains controversial. Our former modeling studies have selected the 'Direct Activation Model' as a better...

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Bibliographic Details
Main Authors: Jun Cui, Chun Chen, Haizhu Lu, Tingzhe Sun, Pingping Shen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/18213378/pdf/?tool=EBI

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