Primate Cerebellar Granule Cells Exhibit a Tonic GABAAR Conductance that is not Affected by Alcohol: A Possible Cellular Substrate of the Low Level of Response Phenotype.

Primate Cerebellar Granule Cells Exhibit a Tonic GABAAR Conductance that is not Affected by Alcohol: A Possible Cellular Substrate of the Low Level of Response Phenotype.

In many rodent brain regions, alcohol increases vesicular release of GABA, resulting in an increase in the frequency of spontaneous inhibitory postsynaptic currents (sIPSCs) and the magnitude of tonic GABAA receptor (GABAAR) currents. A neglected issue in translating the rodent literature to humans...

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Bibliographic Details
Main Authors: Claudia eMohr, Olena eKolotushkina, Joshua S Kaplan, John eWelsh, James eDaunais, Kathleen eGrant, David James Rossi
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-11-01
Series:Frontiers in Neural Circuits
Subjects:
Alcohol Drinking
Cerebellum
Ethanol
GABA Modulators
Primate
GABA-A receptor
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncir.2013.00189/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fncir.2013.00189/full

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