Phosphoinositide-3-kinases p110alpha and p110beta mediate S phase entry in astroglial cells in the marginal zone of rat neocortex

Phosphoinositide-3-kinases p110alpha and p110beta mediate S phase entry in astroglial cells in the marginal zone of rat neocortex

In cells cultured from neocortex of newborn rats, phosphoinositide-3-kinases of class I regulate the DNA synthesis in a subgroup of astroglial cells. We have studied the location of these cells as well as the kinase isoforms which facilitate the S phase entry. Using dominant negative isoforms as we...

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Bibliographic Details
Main Authors: Rabea eMüller, Catharina eFischer, Thomas eWilmes, Bernd eHeimrich, Vanessa eDistel, Norbert eKlugbauer, Dieter Klaus Meyer
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-03-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Neocortex
proliferation
marginal zone
p110α
p110b
GSK3b
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2013.00024/full

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