Interleukin-6 induces S100A9 expression in colonic epithelial cells through STAT3 activation in experimental ulcerative colitis.

Interleukin-6 induces S100A9 expression in colonic epithelial cells through STAT3 activation in experimental ulcerative colitis.

BACKGROUND: Intestinal epithelium is essential for maintaining normal intestinal homeostasis; its breakdown leads to chronic inflammatory pathologies, such as inflammatory bowel diseases (IBDs). Although high concentrations of S100A9 protein and interleukin-6 (IL-6) are found in patients with IBD, t...

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Main Authors: Min Jeoung Lee, Jin-Ku Lee, Ji Won Choi, Chang-Seok Lee, Ji Hyun Sim, Chung-Hyun Cho, Kwang-Ho Lee, Ik-Hyun Cho, Myung-Hee Chung, Hang-Rae Kim, Sang-Kyu Ye
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3433486?pdf=render

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http://europepmc.org/articles/PMC3433486?pdf=render

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