UTX is an escape from X-inactivation tumor-suppressor in B cell lymphoma

UTX is an escape from X-inactivation tumor-suppressor in B cell lymphoma

UTX is a tumor suppressor gene located on the X-chromosome so it could potentially contribute to the cancer gender bias. Here the authors, using a mouse model of B cell lymphoma, show that UTX is a dosage sensitive tumor suppressor and may be responsible for some of the increased incidence and possi...

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Bibliographic Details
Main Authors: Xiaoxi Li, Yanli Zhang, Liting Zheng, Mingxian Liu, Charlie Degui Chen, Hai Jiang
Format: Article
Language:English
Published: Nature Publishing Group 2018-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-05084-w
Description
Summary:UTX is a tumor suppressor gene located on the X-chromosome so it could potentially contribute to the cancer gender bias. Here the authors, using a mouse model of B cell lymphoma, show that UTX is a dosage sensitive tumor suppressor and may be responsible for some of the increased incidence and possibly aggressiveness of male cancers that harbour UTX mutations.
ISSN:2041-1723

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