Recurrent aseptic meningitis in association with Kikuchi-Fujimoto disease: case report and literature review

• Main Authors: Komagamine Tomoko, Nagashima Takahide, Kojima Masaru, Kokubun Norito, Nakamura Toshiki, Hashimoto Kenich, Kimoto Kazuhito, Hirata Koichi
• Format: Article
• Language: English
• Published: BMC 2012-09-01
• Series: BMC Neurology
• Subjects: Recurrent aseptic meningitis; Kikuchi-Fujimoto disease; Histiocytic necrotising lymphadenitis; SLE
• Online Access: http://www.biomedcentral.com/1471-2377/12/112

<p>Abstract</p> <p>Background</p> <p>Kikuchi Fujimoto disease (KFD), or histiocytic necrotising lymphadenitis, is a benign and self-limiting condition characterised by primarily affecting the cervical lymph nodes. Recurrent aseptic meningitis in association with KFD is extremely rare and remains a diagnostic challenge.</p> <p>Case presentation</p> <p>We report a 28-year-old man who presented 7 episodes of aseptic meningitis associated with KFD over the course of 7 years. Histopathological findings of enlarged lymph nodes led to the diagnosis of KFD. The patient’s headache and lymphadenopathy spontaneously resolved without any sequelae.</p> <p>Conclusions</p> <p>A diagnosis of KFD should be considered when enlarged cervical lymph nodes are observed in patients with recurrent aseptic meningitis. A long-term prognosis remains uncertain, and careful follow-up is preferred.</p>