Tonic Control of Secretory Acid Sphingomyelinase Over Ventral Hippocampal Synaptic Transmission and Neuron Excitability

Tonic Control of Secretory Acid Sphingomyelinase Over Ventral Hippocampal Synaptic Transmission and Neuron Excitability

The acid sphingomyelinase (ASM) converts sphingomyelin into ceramide. Recent work has advanced the ASM/ceramide system as a major player in the pathogenesis of major depressive disorder (MDD). Indeed, ASM activity is enhanced in MDD patients and antidepressant drugs like fluoxetine act as functional...

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Bibliographic Details
Main Authors: Chih-Hung Lin, Johannes Kornhuber, Fang Zheng, Christian Alzheimer
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Cellular Neuroscience
Subjects:
acid sphingomyelinase
ventral hippocampus
pyramidal cells
action potentials
EPSC
IPSC
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2021.660561/full

Internet

https://www.frontiersin.org/articles/10.3389/fncel.2021.660561/full

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