Impact of phenylalanine on cognitive, cerebral, and neurometabolic parameters in adult patients with phenylketonuria (the PICO study): a randomized, placebo-controlled, crossover, noninferiority trial

Impact of phenylalanine on cognitive, cerebral, and neurometabolic parameters in adult patients with phenylketonuria (the PICO study): a randomized, placebo-controlled, crossover, noninferiority trial

Abstract Background The population of adult patients with early-treated phenylketonuria (PKU) following newborn screening is growing substantially. The ideal target range of blood phenylalanine (Phe) levels in adults outside pregnancy is a matter of debate. Therefore, prospective intervention studie...

Full description

Bibliographic Details
Main Authors: Roman Trepp, Raphaela Muri, Stephanie Abgottspon, Lenka Bosanska, Michel Hochuli, Johannes Slotboom, Christian Rummel, Roland Kreis, Regula Everts
Format: Article
Language:English
Published: BMC 2020-02-01
Series:Trials
Subjects:
Phenylketonuria
PKU
Phenylalanine
Diet
Neuropsychology
Working memory
Online Access:https://doi.org/10.1186/s13063-019-4022-z

Internet

https://doi.org/10.1186/s13063-019-4022-z

Similar Items