Isodeoxyelephantopin Inactivates Thioredoxin Reductase 1 and Activates ROS-Mediated JNK Signaling Pathway to Exacerbate Cisplatin Effectiveness in Human Colon Cancer Cells

Isodeoxyelephantopin Inactivates Thioredoxin Reductase 1 and Activates ROS-Mediated JNK Signaling Pathway to Exacerbate Cisplatin Effectiveness in Human Colon Cancer Cells

Colon cancer is one of the leading causes of cancer-related death in the world. The development of new drugs and therapeutic strategies for patients with colon cancer are urgently needed. Isodeoxyelephantopin (ESI), a sesquiterpene lactone isolated from the medicinal plant Elephantopus scaber L., ha...

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Bibliographic Details
Main Authors: Lin Hong, Jundixia Chen, Fang Wu, Fengjiao Wu, Xin Shen, Peisen Zheng, Rongrong Shao, Kongqin Lu, Zhiguo Liu, Daoxing Chen, Guang Liang, Yuepiao Cai, Peng Zou, Yiqun Xia
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
isodeoxyelephantopin
oxidative stress
thioredoxin reductase 1
cisplatin
JNK
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2020.580517/full

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