Tryptophan Metabolism and Its Relationship with Depression and Cognitive Impairment among HIV-infected Individuals
Objective Cognitive impairment (CI) and major depressive disorder (MDD) remain prevalent in treated HIV-1 disease; however, the pathogenesis remains elusive. A possible contributing mechanism is immune-mediated degradation of tryptophan (TRP) via the kynurenine (KYN) pathway, resulting in decreased...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2016-01-01
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| Series: | International Journal of Tryptophan Research |
| Online Access: | https://doi.org/10.4137/IJTR.S36464 |
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by Michael R. Keegan, Seetharamaiah Chittiprol, Scott L. Letendre, Alan Winston, Dietmar Fuchs, Adriano Boasso, Jennifer Iudicello, Ronald J. Ellis
Published 2016-10-01
Get full textPublished 2016-10-01
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