Hypoxic stabilization of mRNA is HIF-independent but requires mtROS

Hypoxic stabilization of mRNA is HIF-independent but requires mtROS

Abstract Background Tissue ischemia can arise in response to numerous physiologic and pathologic conditions. The cellular response to decreased perfusion, most notably a decrease in glucose and oxygen, is important for cellular survival. In response to oxygen deprivation or hypoxia, one of the key r...

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Bibliographic Details
Main Authors: Grey W Fortenbery, Brinda Sarathy, Kristen R Carraway, Kyle D Mansfield
Format: Article
Language:English
Published: BMC 2018-10-01
Series:Cellular & Molecular Biology Letters
Subjects:
Hypoxia
Hypoglycemia
HIF
Mitochondrial reactive oxygen species
mRNA stability
Online Access:http://link.springer.com/article/10.1186/s11658-018-0112-2

Internet

http://link.springer.com/article/10.1186/s11658-018-0112-2

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