DOSAGE OF VITAMIN D IN CHILDREN AND ADOLESCENTS

• Main Authors: O. A. Gromova, I. Yu. Torshin, I. N. Zakharova, V. B. Spirichev, O. A. Limanova, T. E. Borovik, G V. Yatsyk
• Format: Article
• Language: English
• Published: "Paediatrician" Publishers LLC 2015-02-01
• Series: Voprosy Sovremennoj Pediatrii
• Subjects: сhildren; vitamin d; 25(oh)d; rate; intake; safety
• Online Access: https://vsp.spr-journal.ru/jour/article/view/80
• ISSN: 1682-5527; 1682-5535

The data of modern basic and clinical studies demonstrate that commonly used rates of the recommended daily intake of vitamin D for children (400–500 IU/day) are significantly underestimated. The article presents the results of survey and clinical studies (n =21), in which the positive dynamics of 25(OH)D concentration in the blood plasma during intake of vitamin D is noted in children and adolescents aged from 0 to 18 years. The duration of vitamin D intake in the analysed studies was from 1 to 12 months, the dose — from 800 to 4000 IU/day. According to the results of the age-specific analysis, the staircase scheme of vitamin D prescription is offered: for children aged under 4 months the daily intake of 500 IU/day of the vitamin is recommended during a year (for premature — 800-1000 IU/day), aged from 4 months to 4 years — 1000 IU/day, 4–10 years — 1500 IU/day, 10–16 years — 2000 IU/day. Therewith, this achieves the effective compensation of vitamin D deficiency (25(OH)D concentration >20 ng/ml), and also, according to some reports, the reduction of risks of infectious and allergic diseases. Safety of the recommended vitamin D intake mode is shown.