Over-Generalizing About GC (Hypoxia): Pitfalls of Limiting Breadth of Experimental Systems and Analyses in Framing Informatics Conclusions

Over-Generalizing About GC (Hypoxia): Pitfalls of Limiting Breadth of Experimental Systems and Analyses in Framing Informatics Conclusions

Accumulating evidence suggests that many immune responses are influenced by local nutrient concentrations in addition to the programming of intermediary metabolism within immune cells. Humoral immunity and germinal centers (GC) are settings in which these factors are under active investigation. Hypo...

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Bibliographic Details
Main Authors: Mark R. Boothby, Ariel Raybuck, Sung Hoon Cho, Kristy R. Stengel, Volker H. Haase, Scott Hiebert, Jingxin Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Immunology
Subjects:
hypoxia
intermediary metabolism
Germinal center (GC) B cells
RNA-Seq
polyclonal preimmune repertoire
BCR transgenic mice
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.664249/full

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