Resveratrol Sensitizes Selectively Thyroid Cancer Cell to 131-Iodine Toxicity

• Main Authors: Seyed Jalal Hosseinimehr, Seyed Amir Hossein Hosseini
• Format: Article
• Language: English
• Published: Hindawi Limited 2014-01-01
• Series: Journal of Toxicology
• Online Access: http://dx.doi.org/10.1155/2014/839597

Background. In this study, the radiosensitizing effect of resveratrol as a natural product was investigated on cell toxicity induced by 131I in thyroid cancer cell. Methods. Human thyroid cancer cell and human nonmalignant fibroblast cell (HFFF2) were treated with 131I and/or resveratrol at different concentrations for 48 h. The cell proliferation was measured by determination of the percent of the survival cells using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Results. Findings of this study show that resveratrol enhanced the cell death induced by 131I on thyroid cancer cell. Also, resveratrol exhibited a protective effect on normal cells against 131I toxicity. Conclusion. This result indicates a promising effect of resveratrol on improvement of cellular toxicity during iodine therapy.