In silico investigation of the short QT syndrome, using human ventricle models incorporating electromechanical coupling

In silico investigation of the short QT syndrome, using human ventricle models incorporating electromechanical coupling

Introduction Genetic forms of the Short QT Syndrome (SQTS) arise due to cardiac ion channel mutations leading to accelerated ventricular repolarisation, arrhythmias and sudden cardiac death. Results from experimental and simulation studies suggest that changes to refractoriness and tissue vulnerabi...

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Bibliographic Details
Main Authors: Ismail eAdeniran, Juldes eHancox, Henggui eZhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-07-01
Series:Frontiers in Physiology
Subjects:
Short QT Syndrome;
Stretch-activated channel;
Mechanical contraction;
3D model;
Human ventricles
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphys.2013.00166/full

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