Fenofibrate Decreases Hepatic P-Glycoprotein in a Rat Model of Hereditary Hypertriglyceridemia

Fenofibrate Decreases Hepatic P-Glycoprotein in a Rat Model of Hereditary Hypertriglyceridemia

P-glycoprotein (P-gp) is a membrane-bound transporter encoded by Mdr1a/Abcb1a and Mdr1b/Abcb1b genes in rodents involved in the efflux of cytotoxic chemicals and metabolites from cells. Modulation of its activity influences P-gp-mediated drug delivery and drug-drug interaction (DDI). In the current...

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Bibliographic Details
Main Authors: Martin Poruba, Zuzana Matuskova, Martina Hüttl, Hana Malinska, Olena Oliyarnyk, Irena Markova, Sona Gurska, Ludmila Kazdova, Rostislav Vecera
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-02-01
Series:Frontiers in Pharmacology
Subjects:
fenofibrate
P-glycoprotein
Mdr1
drug-drug interactions
hypertriglyceridemia
metabolic syndrome
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.00056/full

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https://www.frontiersin.org/article/10.3389/fphar.2019.00056/full

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