Next-generation Sequencing-based genomic profiling: Fostering innovation in cancer care?

Next-generation Sequencing-based genomic profiling: Fostering innovation in cancer care?

OBJECTIVES: With the development of next-generation sequencing (NGS) technologies, DNA sequencing has been increasingly utilized in clinical practice. Our goal was to investigate the impact of genomic evaluation on treatment decisions for heavily pretreated patients with metastatic cancer. METHODS:...

Full description

Bibliographic Details
Main Authors:	Gustavo S. Fernandes, Daniel F. Marques, Daniel M. Girardi, Maria Ignez F. Braghiroli, Renata A. Coudry, Sibele I. Meireles, Artur Katz, Paulo M. Hoff
Format:	Article
Language:	English
Published:	Faculdade de Medicina / USP
Series:	Clinics
Subjects:	Molecular Profiling Targeted Therapy Precision Refractory
Online Access:	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322017001000588&lng=en&tlng=en

Similar Items

Next-generation sequencing: recent applications to the analysis of colorectal cancer
by: Filippo Del Vecchio, et al.
Published: (2017-12-01)

Next-Generation Sequencing pada Kanker Paru
by: Hana Khairina Putri Faisal, et al.
Published: (2020-10-01)

Refractory Metastatic Colorectal Cancer: Current Challenges and Future Prospects
by: Lam M, et al.
Published: (2020-07-01)

Next-Generation Sequencing Identifies Potential Actionable Targets in Paediatric Sarcomas
by: Antonio Juan Ribelles, et al.
Published: (2021-04-01)

Precision medicine in relapsed or refractory pediatric solid tumors: a collaborative Spanish initiative
by: Pablo Gargallo, et al.
Published: (2019-07-01)

High performance of targeted next generation sequencing on variance detection in clinical tumor specimens in comparison with current conventional methods
by: Dan Su, et al.
Published: (2017-09-01)

Therapeutic relevance of molecular screening program in patients with metastatic sarcoma: Analysis from the ProfiLER 01 trial
by: Patrick Arnaud-Coffin, et al.
Published: (2020-12-01)

Targeted Gene Next-Generation Sequencing Panel in Patients with Advanced Lung Adenocarcinoma: Paving the Way for Clinical Implementation
by: Maria Gabriela O. Fernandes, et al.
Published: (2019-08-01)

When should we order a next generation sequencing test in a patient with cancer?
by: Ramon Colomer, et al.
Published: (2020-08-01)

Precision Medicine for the Management of Therapy Refractory Colorectal Cancer
by: Hossein Taghizadeh, et al.
Published: (2020-12-01)

Next-Generation Sequencing in Acute Lymphoblastic Leukemia
by: Nicoletta Coccaro, et al.
Published: (2019-06-01)

Progress: Targeted Therapy, Immunotherapy, and New Chemotherapy Strategies in Advanced Triple-Negative Breast Cancer
by: Shi J, et al.
Published: (2020-09-01)

Targeted next generation sequencing identified clinically actionable mutations in patients with esophageal sarcomatoid carcinoma
by: Hongyang Lu, et al.
Published: (2018-03-01)

GENOME EDITING: PROPELLING THE NEXT GENERATION OF CROP IMPROVEMENT
by: Jéssika Angelotti-Mendonça, et al.
Published: (2021-08-01)

Next-Generation Sequencing-Directed Therapy in Patients with Metastatic Breast Cancer in Routine Clinical Practice
by: Simona Bruzas, et al.
Published: (2021-09-01)

Long-term overall survival and prognostic score predicting survival: the IMPACT study in precision medicine
by: Apostolia-Maria Tsimberidou, et al.
Published: (2019-12-01)

Targeted Therapy Recommendations for Therapy Refractory Solid Tumors—Data from the Real-World Precision Medicine Platform MONDTI
by: Hossein Taghizadeh, et al.
Published: (2020-10-01)

Statistical Process Control Charts for Monitoring Next-Generation Sequencing and Bioinformatics Turnaround in Precision Medicine Initiatives
by: Sneha Rajiv Jain, et al.
Published: (2021-09-01)

New Era for Next-Generation Sequencing in Japan
by: Masayuki Takeda, et al.
Published: (2019-05-01)

CHEMOTHERAPY FOR HORMONE REFRACTORY PROSTATE CANCER
by: Ya. V. Gridneva, et al.
Published: (2014-08-01)

CHEMOTHERAPY FOR HORMONE REFRACTORY PROSTATE CANCER
by: Ya. V. Gridneva, et al.
Published: (2014-08-01)

miRTil: An Extensive Repository for Nile Tilapia microRNA Next Generation Sequencing Data
by: Luiz Augusto Bovolenta, et al.
Published: (2020-07-01)

Effective Treatment with PD-1 Antibody, Chidamide, Etoposide, and Thalidomide (PCET) for Relapsed/Refractory Natural Killer/T-Cell Lymphoma: A Report of Three Cases
by: Du L, et al.
Published: (2020-07-01)

Computational Methods for the Pharmacogenetic Interpretation of Next Generation Sequencing Data
by: Yitian Zhou, et al.
Published: (2018-12-01)

The Tip of the Iceberg: Clinical Implications of Genomic Sequencing Projects in Head and Neck Cancer
by: Andrew C. Birkeland, et al.
Published: (2015-10-01)

Intermediate Results of Prospective Observational Study: The 2-year Experience of Ibrutinib Therapy in Relapsed/Refractory Mantle Cell Lymphoma in Clinical Practice
by: VI Vorob’ev, et al.
Published: (2019-03-01)

Changing paradigm of cancer therapy: precision medicine by next-generation sequencing
by: Yuan Xue, et al.
Published: (2016-03-01)

Transitioning the Molecular Tumor Board from Proof of Concept to Clinical Routine: A German Single-Center Analysis
by: Rouven Hoefflin, et al.
Published: (2021-03-01)

REFRACTORY THROMBOCYTOPENIA AND NEUTROPENIA: A DIAGNOSTIC CHALLENGE
by: Emmanuel Gyan, et al.
Published: (2015-02-01)

Impact of Next-Generation Sequencing on Outcomes in Hepatocellular Carcinoma: How Precise Are We Really?
by: Dominguez DA, et al.
Published: (2020-03-01)

Fine‐needle aspiration as an alternative to core needle biopsy for tumour molecular profiling in precision oncology: prospective comparative study of next‐generation sequencing in cancer patients included in the SHIVA02 trial
by: Célia Dupain, et al.
Published: (2021-01-01)

Control for stochastic sampling variation and qualitative sequencing error in next generation sequencing
by: Thomas Blomquist, et al.
Published: (2015-09-01)

Sequencing of Nucleic Acids: from the First Human Genome to Next Generation Sequencing in COVID-19 Pandemic
by: Borut Furlani, et al.
Published: (2021-06-01)

New Therapies for Advanced Thyroid Cancer
by: Diprajan Laha, et al.
Published: (2020-05-01)

Deep Brain Stimulation and Drug-Resistant Epilepsy: A Review of the Literature
by: Nasser Zangiabadi, et al.
Published: (2019-06-01)

Outcome based definition of the anterior thalamic deep brain stimulation target in refractory epilepsy
by: K. Lehtimäki, et al.
Published: (2016-03-01)

Combining molecular and imaging metrics in cancer: radiogenomics
by: Roberto Lo Gullo, et al.
Published: (2020-01-01)

Clinically available RNA profiling tests of prostate tumors: utility and comparison
by: Rong Na, et al.
Published: (2016-01-01)

Single Cell Sequencing of the Pineal Gland: The Next Chapter
by: Steven L. Coon, et al.
Published: (2019-09-01)

Comprehensive molecular profiling of Taiwanese breast cancers revealed potential therapeutic targets: prevalence of actionable mutations among 380 targeted sequencing analyses
by: Chi-Cheng Huang, et al.
Published: (2021-02-01)

Cannot write session to /tmp/vufind_sessions/sess_jp1bpnm1322oi7bl6e2lrfgt65