Loss of VHL in RCC reduces repair and alters cellular response to benzo[a]pyrene

Loss of VHL in RCC reduces repair and alters cellular response to benzo[a]pyrene

Mutations of the von Hippel-Lindau (VHL) tumor suppressor gene occur in the majority of sporadic renal-cell carcinomas (RCC). Loss of VHL function is associated with stabilization of hypoxia-inducible factor α (HIFα). We and others demonstrated that there is a two-way interaction between the aryl hy...

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Bibliographic Details
Main Authors: Marten eSchults, Yvonne eOligschlaeger, Roger eGodschalk, Frederik-Jan evan Schooten, Roland eChiu
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-10-01
Series:Frontiers in Oncology
Subjects:
Carcinogens
Metabolism
Renal cell carcinoma
von Hippel-Lindau
nucleotide excision repair
Online Access:http://journal.frontiersin.org/Journal/10.3389/fonc.2013.00270/full

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