Variable Responses to CFTR Correctors in vitro: Estimating the Design Effect in Precision Medicine

Variable Responses to CFTR Correctors in vitro: Estimating the Design Effect in Precision Medicine

Interest in precision medicine has grown in recent years due to the variable clinical benefit provided by some medications, their cost, and by new opportunities to tailor therapies to individual patients. In cystic fibrosis it may soon be possible to test several corrector drugs that improve the fol...

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Bibliographic Details
Main Authors: Elizabeth Matthes, Julie Goepp, Carolina Martini, Jiajie Shan, Jie Liao, David Y. Thomas, John W. Hanrahan
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-12-01
Series:Frontiers in Pharmacology
Subjects:
precision medicine
cystic fibrosis
correctors
lumacaftor
Orkambi
group sampling
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.01490/full

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