Poly(ester amide)-Poly(ethylene oxide) Graft Copolymers: Towards Micellar Drug Delivery Vehicles

Poly(ester amide)-Poly(ethylene oxide) Graft Copolymers: Towards Micellar Drug Delivery Vehicles

Micelles formed from amphiphilic copolymers are promising materials for the delivery of drug molecules, potentially leading to enhanced biological properties and efficacy. In this work, new poly(ester amide)-poly(ethylene oxide) (PEA-PEO) graft copolymers were synthesized and their assembly into mic...

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Main Authors: Gregory J. Zilinskas, Abdolrasoul Soleimani, Elizabeth R. Gillies
Format: Article
Language:English
Published: Hindawi Limited 2012-01-01
Series:International Journal of Polymer Science
Online Access:http://dx.doi.org/10.1155/2012/564348
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spelling doaj-111bf91534024109b3d928dc62d8d52d2020-11-24T23:56:02ZengHindawi LimitedInternational Journal of Polymer Science1687-94221687-94302012-01-01201210.1155/2012/564348564348Poly(ester amide)-Poly(ethylene oxide) Graft Copolymers: Towards Micellar Drug Delivery VehiclesGregory J. Zilinskas0Abdolrasoul Soleimani1Elizabeth R. Gillies2Biomedical Engineering Graduate Program, The University of Western Ontario, 1151 Richmond Street, London, ON, N6A 5B7, CanadaDepartment of Chemical and Biochemical Engineering, The University of Western Ontario, 1151 Richmond Street, London, ON, N6A 5B7, CanadaDepartment of Chemical and Biochemical Engineering, The University of Western Ontario, 1151 Richmond Street, London, ON, N6A 5B7, CanadaMicelles formed from amphiphilic copolymers are promising materials for the delivery of drug molecules, potentially leading to enhanced biological properties and efficacy. In this work, new poly(ester amide)-poly(ethylene oxide) (PEA-PEO) graft copolymers were synthesized and their assembly into micelles in aqueous solution was investigated. It was possible to tune the sizes of the micelles by varying the PEO content of the polymers and the method of micelle preparation. Under optimized conditions, it was possible to obtain micelles with diameters less than 100 nm as measured by dynamic light scattering and transmission electron microscopy. These micelles were demonstrated to encapsulate and release a model drug, Nile Red, and were nontoxic to HeLa cells as measured by an MTT assay. Overall, the properties of these micelles suggest that they are promising new materials for drug delivery systems.http://dx.doi.org/10.1155/2012/564348
collection DOAJ
language English
format Article
sources DOAJ
author Gregory J. Zilinskas
Abdolrasoul Soleimani
Elizabeth R. Gillies
spellingShingle Gregory J. Zilinskas
Abdolrasoul Soleimani
Elizabeth R. Gillies
Poly(ester amide)-Poly(ethylene oxide) Graft Copolymers: Towards Micellar Drug Delivery Vehicles
International Journal of Polymer Science
author_facet Gregory J. Zilinskas
Abdolrasoul Soleimani
Elizabeth R. Gillies
author_sort Gregory J. Zilinskas
title Poly(ester amide)-Poly(ethylene oxide) Graft Copolymers: Towards Micellar Drug Delivery Vehicles
title_short Poly(ester amide)-Poly(ethylene oxide) Graft Copolymers: Towards Micellar Drug Delivery Vehicles
title_full Poly(ester amide)-Poly(ethylene oxide) Graft Copolymers: Towards Micellar Drug Delivery Vehicles
title_fullStr Poly(ester amide)-Poly(ethylene oxide) Graft Copolymers: Towards Micellar Drug Delivery Vehicles
title_full_unstemmed Poly(ester amide)-Poly(ethylene oxide) Graft Copolymers: Towards Micellar Drug Delivery Vehicles
title_sort poly(ester amide)-poly(ethylene oxide) graft copolymers: towards micellar drug delivery vehicles
publisher Hindawi Limited
series International Journal of Polymer Science
issn 1687-9422
1687-9430
publishDate 2012-01-01
description Micelles formed from amphiphilic copolymers are promising materials for the delivery of drug molecules, potentially leading to enhanced biological properties and efficacy. In this work, new poly(ester amide)-poly(ethylene oxide) (PEA-PEO) graft copolymers were synthesized and their assembly into micelles in aqueous solution was investigated. It was possible to tune the sizes of the micelles by varying the PEO content of the polymers and the method of micelle preparation. Under optimized conditions, it was possible to obtain micelles with diameters less than 100 nm as measured by dynamic light scattering and transmission electron microscopy. These micelles were demonstrated to encapsulate and release a model drug, Nile Red, and were nontoxic to HeLa cells as measured by an MTT assay. Overall, the properties of these micelles suggest that they are promising new materials for drug delivery systems.
url http://dx.doi.org/10.1155/2012/564348
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AT abdolrasoulsoleimani polyesteramidepolyethyleneoxidegraftcopolymerstowardsmicellardrugdeliveryvehicles
AT elizabethrgillies polyesteramidepolyethyleneoxidegraftcopolymerstowardsmicellardrugdeliveryvehicles
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