Synthesis and Biological Evaluation of a New Acyclic Pyrimidine Derivative as a Probe for Imaging Herpes Simplex Virus Type 1 Thymidine Kinase Gene Expression

Synthesis and Biological Evaluation of a New Acyclic Pyrimidine Derivative as a Probe for Imaging Herpes Simplex Virus Type 1 Thymidine Kinase Gene Expression

With the idea of finding a more selective radiotracer for imaging herpes simplex virus type 1 thymidine kinase (HSV1-tk) gene expression by means of positron emission tomography (PET), a novel [18F]fluorine radiolabeled pyrimidine with 4-hydroxy-3-(hydroxymethyl)butyl side chain at N-1 (HHB-5-[18F]F...

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Bibliographic Details
Main Authors: Simon M. Ametamey, Silvana Raić-Malić, Stjepko Čermak, Roger Slavik, Adrienne Müller, Thomas Betzel, Andrijana Meščić
Format: Article
Language:English
Published: MDPI AG 2013-07-01
Series:Molecules
Subjects:
acyclic pyrimidine nucleoside analogues
PCV-like side chain
fluorination
radiosynthesis
positron emission tomography (PET)
HSV1-TK
Online Access:http://www.mdpi.com/1420-3049/18/7/8535

Internet

http://www.mdpi.com/1420-3049/18/7/8535

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