Improved Synthesis of 2',6'-Dihydroxy-3,4-dimethoxy Chalcone by Grinding Technique to Synthesize 5-Hydroxy-3',4'-dimethoxy Flavone

5-hydroxy-3',4'-dimethoxy flavone can be efficiently synthesized in two steps via the formation of 2',6'-dihydroxy-3,4-dimethoxy chalcone with good results. 2',6'-dihydroxy-3,4-dimethoxy chalcone as reactants for synthesis of flavones was prepared through Claisen-Schmid...

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Main Authors:	Elfi Susanti VH, Sabirin Matsjeh, Mustofa Mustofa, Tutik Dwi Wahyuningsih
Format:	Article
Language:	English
Published:	Universitas Gadjah Mada 2014-07-01
Series:	Indonesian Journal of Chemistry
Subjects:	chalcone flavone Claisen-Schmidt grinding
Online Access:	https://jurnal.ugm.ac.id/ijc/article/view/21255

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spelling	doaj-1113028745be4832864d024a121f2a1e2020-11-24T21:55:58ZengUniversitas Gadjah MadaIndonesian Journal of Chemistry1411-94202460-15782014-07-0114217417810.22146/ijc.2125514353Improved Synthesis of 2',6'-Dihydroxy-3,4-dimethoxy Chalcone by Grinding Technique to Synthesize 5-Hydroxy-3',4'-dimethoxy FlavoneElfi Susanti VH0Sabirin Matsjeh1Mustofa Mustofa2Tutik Dwi Wahyuningsih3Department of Chemistry FKIP Universitas Sebelas Maret, Ir Sutami 36A Surakarta 57126Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Gadjah Mada, Sekip Utara Yogyakarta 55281Faculty of Medicine, Universitas Gadjah Mada, Jl. Sekip Utara Yogyakarta 55281Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Gadjah Mada, Sekip Utara Yogyakarta 552815-hydroxy-3',4'-dimethoxy flavone can be efficiently synthesized in two steps via the formation of 2',6'-dihydroxy-3,4-dimethoxy chalcone with good results. 2',6'-dihydroxy-3,4-dimethoxy chalcone as reactants for synthesis of flavones was prepared through Claisen-Schmidt condensation reaction between 2,6-dihydroxyacetophenones,3,4-dimethoxybenzaldehyde and solid NaOH in mortar for 15 min. The yield of the product (70%) is higher than conventional method (65%). This chalcone then oxidatively cyclized with iodine to form 5-hydroxy-3',4'-dimethoxy flavone (yield 62%). Compounds synthesized were characterized by spectroscopic (IR, 1H-NMR, and 13C-NMR).https://jurnal.ugm.ac.id/ijc/article/view/21255chalconeflavoneClaisen-Schmidtgrinding
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Elfi Susanti VH Sabirin Matsjeh Mustofa Mustofa Tutik Dwi Wahyuningsih
spellingShingle	Elfi Susanti VH Sabirin Matsjeh Mustofa Mustofa Tutik Dwi Wahyuningsih Improved Synthesis of 2',6'-Dihydroxy-3,4-dimethoxy Chalcone by Grinding Technique to Synthesize 5-Hydroxy-3',4'-dimethoxy Flavone Indonesian Journal of Chemistry chalcone flavone Claisen-Schmidt grinding
author_facet	Elfi Susanti VH Sabirin Matsjeh Mustofa Mustofa Tutik Dwi Wahyuningsih
author_sort	Elfi Susanti VH
title	Improved Synthesis of 2',6'-Dihydroxy-3,4-dimethoxy Chalcone by Grinding Technique to Synthesize 5-Hydroxy-3',4'-dimethoxy Flavone
title_short	Improved Synthesis of 2',6'-Dihydroxy-3,4-dimethoxy Chalcone by Grinding Technique to Synthesize 5-Hydroxy-3',4'-dimethoxy Flavone
title_full	Improved Synthesis of 2',6'-Dihydroxy-3,4-dimethoxy Chalcone by Grinding Technique to Synthesize 5-Hydroxy-3',4'-dimethoxy Flavone
title_fullStr	Improved Synthesis of 2',6'-Dihydroxy-3,4-dimethoxy Chalcone by Grinding Technique to Synthesize 5-Hydroxy-3',4'-dimethoxy Flavone
title_full_unstemmed	Improved Synthesis of 2',6'-Dihydroxy-3,4-dimethoxy Chalcone by Grinding Technique to Synthesize 5-Hydroxy-3',4'-dimethoxy Flavone
title_sort	improved synthesis of 2',6'-dihydroxy-3,4-dimethoxy chalcone by grinding technique to synthesize 5-hydroxy-3',4'-dimethoxy flavone
publisher	Universitas Gadjah Mada
series	Indonesian Journal of Chemistry
issn	1411-9420 2460-1578
publishDate	2014-07-01
description	5-hydroxy-3',4'-dimethoxy flavone can be efficiently synthesized in two steps via the formation of 2',6'-dihydroxy-3,4-dimethoxy chalcone with good results. 2',6'-dihydroxy-3,4-dimethoxy chalcone as reactants for synthesis of flavones was prepared through Claisen-Schmidt condensation reaction between 2,6-dihydroxyacetophenones,3,4-dimethoxybenzaldehyde and solid NaOH in mortar for 15 min. The yield of the product (70%) is higher than conventional method (65%). This chalcone then oxidatively cyclized with iodine to form 5-hydroxy-3',4'-dimethoxy flavone (yield 62%). Compounds synthesized were characterized by spectroscopic (IR, 1H-NMR, and 13C-NMR).
topic	chalcone flavone Claisen-Schmidt grinding
url	https://jurnal.ugm.ac.id/ijc/article/view/21255
work_keys_str_mv	AT elfisusantivh improvedsynthesisof26dihydroxy34dimethoxychalconebygrindingtechniquetosynthesize5hydroxy34dimethoxyflavone AT sabirinmatsjeh improvedsynthesisof26dihydroxy34dimethoxychalconebygrindingtechniquetosynthesize5hydroxy34dimethoxyflavone AT mustofamustofa improvedsynthesisof26dihydroxy34dimethoxychalconebygrindingtechniquetosynthesize5hydroxy34dimethoxyflavone AT tutikdwiwahyuningsih improvedsynthesisof26dihydroxy34dimethoxychalconebygrindingtechniquetosynthesize5hydroxy34dimethoxyflavone
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Improved Synthesis of 2',6'-Dihydroxy-3,4-dimethoxy Chalcone by Grinding Technique to Synthesize 5-Hydroxy-3',4'-dimethoxy Flavone

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