Multifocal cocaine-induced pyoderma gangrenosum: A report of two cases and review of literature

Multifocal cocaine-induced pyoderma gangrenosum: A report of two cases and review of literature

Pyoderma gangrenosum is often associated with a systemic disease. Cocaine-induced pyoderma gangrenosum, most probably caused by levamisole, has been described recently and typically presents as multiple, large cribriform ulcers. Peri-nuclear antineutrophil cytoplasmic antibody is the most common ser...

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Main Authors: Alexandre Lemieux, Zhuo Ran Cai, Annie Belisle, Suzanne Chartier, Chantal Bolduc
Format: Article
Language:English
Published: SAGE Publishing 2020-08-01
Series:SAGE Open Medical Case Reports
Online Access:https://doi.org/10.1177/2050313X20935736
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spelling doaj-110b90cf5033462f9490cefdd6cc9db72020-11-25T03:48:12ZengSAGE PublishingSAGE Open Medical Case Reports2050-313X2020-08-01810.1177/2050313X20935736Multifocal cocaine-induced pyoderma gangrenosum: A report of two cases and review of literatureAlexandre Lemieux0Zhuo Ran Cai1Annie Belisle2Suzanne Chartier3Chantal Bolduc4Department of Medicine, Division of Dermatology, Centre Hospitalier de l’Université de Montréal (CHUM), Montréal, QC, CanadaDepartment of Medicine, Division of Dermatology, Centre Hospitalier de l’Université de Montréal (CHUM), Montréal, QC, CanadaDepartment of Pathology, Centre Hospitalier de l’Université de Montréal (CHUM), Montréal, QC, CanadaDepartment of Medicine, Division of Dermatology, Centre Hospitalier de l’Université de Montréal (CHUM), Montréal, QC, CanadaDepartment of Medicine, Division of Dermatology, Centre Hospitalier de l’Université de Montréal (CHUM), Montréal, QC, CanadaPyoderma gangrenosum is often associated with a systemic disease. Cocaine-induced pyoderma gangrenosum, most probably caused by levamisole, has been described recently and typically presents as multiple, large cribriform ulcers. Peri-nuclear antineutrophil cytoplasmic antibody is the most common serological finding. A strong counseling for cocaine cessation, combined with wound care and immunosuppressive therapy, is the mainstay of treatment. We present two cases of cocaine-induced pyoderma gangrenosum and correlate their findings with the typical clinical, histological and serological presentation.https://doi.org/10.1177/2050313X20935736
collection DOAJ
language English
format Article
sources DOAJ
author Alexandre Lemieux
Zhuo Ran Cai
Annie Belisle
Suzanne Chartier
Chantal Bolduc
spellingShingle Alexandre Lemieux
Zhuo Ran Cai
Annie Belisle
Suzanne Chartier
Chantal Bolduc
Multifocal cocaine-induced pyoderma gangrenosum: A report of two cases and review of literature
SAGE Open Medical Case Reports
author_facet Alexandre Lemieux
Zhuo Ran Cai
Annie Belisle
Suzanne Chartier
Chantal Bolduc
author_sort Alexandre Lemieux
title Multifocal cocaine-induced pyoderma gangrenosum: A report of two cases and review of literature
title_short Multifocal cocaine-induced pyoderma gangrenosum: A report of two cases and review of literature
title_full Multifocal cocaine-induced pyoderma gangrenosum: A report of two cases and review of literature
title_fullStr Multifocal cocaine-induced pyoderma gangrenosum: A report of two cases and review of literature
title_full_unstemmed Multifocal cocaine-induced pyoderma gangrenosum: A report of two cases and review of literature
title_sort multifocal cocaine-induced pyoderma gangrenosum: a report of two cases and review of literature
publisher SAGE Publishing
series SAGE Open Medical Case Reports
issn 2050-313X
publishDate 2020-08-01
description Pyoderma gangrenosum is often associated with a systemic disease. Cocaine-induced pyoderma gangrenosum, most probably caused by levamisole, has been described recently and typically presents as multiple, large cribriform ulcers. Peri-nuclear antineutrophil cytoplasmic antibody is the most common serological finding. A strong counseling for cocaine cessation, combined with wound care and immunosuppressive therapy, is the mainstay of treatment. We present two cases of cocaine-induced pyoderma gangrenosum and correlate their findings with the typical clinical, histological and serological presentation.
url https://doi.org/10.1177/2050313X20935736
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AT anniebelisle multifocalcocaineinducedpyodermagangrenosumareportoftwocasesandreviewofliterature
AT suzannechartier multifocalcocaineinducedpyodermagangrenosumareportoftwocasesandreviewofliterature
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