Caenorhabditis elegans expressing the Saccharomyces cerevisiae NADH alternative dehydrogenase Ndi1p, as a tool to identify new genes involved in complex I related diseases

Caenorhabditis elegans expressing the Saccharomyces cerevisiae NADH alternative dehydrogenase Ndi1p, as a tool to identify new genes involved in complex I related diseases

Isolated complex I deficiencies are one of the most commonly observed biochemical features in patients suffering from mitochondrial disorders. In the majority of these clinical cases the molecular bases of the diseases remain unknown suggesting the involvement of unidentified factors that are critic...

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Bibliographic Details
Main Authors: Raynald eCossard, Michela eEsposito, Carole eSellem, Laras ePitayu, Christelle eVasnier, Agnès eDelahodde, Emmanuel Philippe DASSA
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-06-01
Series:Frontiers in Genetics
Subjects:
Caenorhabditis elegans
Complex I
RNAi screening
Embryonic lethality
Ndi1p
Online Access:http://journal.frontiersin.org/Journal/10.3389/fgene.2015.00206/full

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