Wiggle-predicting functionally flexible regions from primary sequence.

The Wiggle series are support vector machine-based predictors that identify regions of functional flexibility using only protein sequence information. Functionally flexible regions are defined as regions that can adopt different conformational states and are assumed to be necessary for bioactivity....

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Bibliographic Details
Main Authors: Jenny Gu, Michael Gribskov, Philip E Bourne
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2006-07-01
Series:PLoS Computational Biology
Online Access:http://europepmc.org/articles/PMC1500818?pdf=render