Serotype specific epitopes identified by neutralizing antibodies underpin immunogenic differences in Enterovirus B

So far no vaccine or antiviral therapy is available for Echovirus 30 (E30) that causes aseptic meningitis. Here, the authors generate and characterise two E30-specific monoclonal antibodies that block binding of the virus to its attachment receptor CD55 and uncoating receptor FcRn, and determine the...

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Main Authors:	Kang Wang, Binyang Zheng, Li Zhang, Lunbiao Cui, Xuan Su, Qian Zhang, Zhenxi Guo, Yu Guo, Wei Zhang, Ling Zhu, Fengcai Zhu, Zihe Rao, Xiangxi Wang
Format:	Article
Language:	English
Published:	Nature Publishing Group 2020-09-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-020-18250-w

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spelling	doaj-10e58d8f4c94489ea275a5e358714a162021-09-05T11:44:50ZengNature Publishing GroupNature Communications2041-17232020-09-0111111210.1038/s41467-020-18250-wSerotype specific epitopes identified by neutralizing antibodies underpin immunogenic differences in Enterovirus BKang Wang0Binyang Zheng1Li Zhang2Lunbiao Cui3Xuan Su4Qian Zhang5Zhenxi Guo6Yu Guo7Wei Zhang8Ling Zhu9Fengcai Zhu10Zihe Rao11Xiangxi Wang12State Key Laboratory of Medicinal Chemical Biology, College of Life Sciences and College of Pharmacy and Drug Discovery Center for Infectious Diseases, Nankai UniversityState Key Laboratory of Medicinal Chemical Biology, College of Life Sciences and College of Pharmacy and Drug Discovery Center for Infectious Diseases, Nankai UniversityJiangsu Provincial Center for Disease Control and PreventionJiangsu Provincial Center for Disease Control and PreventionState Key Laboratory of Medicinal Chemical Biology, College of Life Sciences and College of Pharmacy and Drug Discovery Center for Infectious Diseases, Nankai UniversityState Key Laboratory of Medicinal Chemical Biology, College of Life Sciences and College of Pharmacy and Drug Discovery Center for Infectious Diseases, Nankai UniversityCryo-EM core facility, School of Life Science, Peking UniversityState Key Laboratory of Medicinal Chemical Biology, College of Life Sciences and College of Pharmacy and Drug Discovery Center for Infectious Diseases, Nankai UniversityState Key Laboratory of Medicinal Chemical Biology, College of Life Sciences and College of Pharmacy and Drug Discovery Center for Infectious Diseases, Nankai UniversityCAS Key Laboratory of Infection and Immunity, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of SciencesJiangsu Provincial Center for Disease Control and PreventionState Key Laboratory of Medicinal Chemical Biology, College of Life Sciences and College of Pharmacy and Drug Discovery Center for Infectious Diseases, Nankai UniversityState Key Laboratory of Medicinal Chemical Biology, College of Life Sciences and College of Pharmacy and Drug Discovery Center for Infectious Diseases, Nankai UniversitySo far no vaccine or antiviral therapy is available for Echovirus 30 (E30) that causes aseptic meningitis. Here, the authors generate and characterise two E30-specific monoclonal antibodies that block binding of the virus to its attachment receptor CD55 and uncoating receptor FcRn, and determine the cryo-EM structures of E30 with the bound neutralizing antibodies.https://doi.org/10.1038/s41467-020-18250-w
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Kang Wang Binyang Zheng Li Zhang Lunbiao Cui Xuan Su Qian Zhang Zhenxi Guo Yu Guo Wei Zhang Ling Zhu Fengcai Zhu Zihe Rao Xiangxi Wang
spellingShingle	Kang Wang Binyang Zheng Li Zhang Lunbiao Cui Xuan Su Qian Zhang Zhenxi Guo Yu Guo Wei Zhang Ling Zhu Fengcai Zhu Zihe Rao Xiangxi Wang Serotype specific epitopes identified by neutralizing antibodies underpin immunogenic differences in Enterovirus B Nature Communications
author_facet	Kang Wang Binyang Zheng Li Zhang Lunbiao Cui Xuan Su Qian Zhang Zhenxi Guo Yu Guo Wei Zhang Ling Zhu Fengcai Zhu Zihe Rao Xiangxi Wang
author_sort	Kang Wang
title	Serotype specific epitopes identified by neutralizing antibodies underpin immunogenic differences in Enterovirus B
title_short	Serotype specific epitopes identified by neutralizing antibodies underpin immunogenic differences in Enterovirus B
title_full	Serotype specific epitopes identified by neutralizing antibodies underpin immunogenic differences in Enterovirus B
title_fullStr	Serotype specific epitopes identified by neutralizing antibodies underpin immunogenic differences in Enterovirus B
title_full_unstemmed	Serotype specific epitopes identified by neutralizing antibodies underpin immunogenic differences in Enterovirus B
title_sort	serotype specific epitopes identified by neutralizing antibodies underpin immunogenic differences in enterovirus b
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2020-09-01
description	So far no vaccine or antiviral therapy is available for Echovirus 30 (E30) that causes aseptic meningitis. Here, the authors generate and characterise two E30-specific monoclonal antibodies that block binding of the virus to its attachment receptor CD55 and uncoating receptor FcRn, and determine the cryo-EM structures of E30 with the bound neutralizing antibodies.
url	https://doi.org/10.1038/s41467-020-18250-w
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Serotype specific epitopes identified by neutralizing antibodies underpin immunogenic differences in Enterovirus B

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