SOD1 regulates ribosome biogenesis in KRAS mutant non-small cell lung cancer

The superoxide dismutase SOD1 is highly expressed in lung cancer but its role has not fully investigated yet. In this study, the authors demonstrate that SOD1 regulates ribosome biogenesis driving KRAS-driven lung tumorigenesis.

Bibliographic Details
Main Authors:	Xiaowen Wang, Hong Zhang, Russell Sapio, Jun Yang, Justin Wong, Xin Zhang, Jessie Y. Guo, Sharon Pine, Holly Van Remmen, Hong Li, Eileen White, Chen Liu, Megerditch Kiledjian, Dimitri G. Pestov, X. F. Steven Zheng
Format:	Article
Language:	English
Published:	Nature Publishing Group 2021-04-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-021-22480-x

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spelling	doaj-10e3267362bc477794a94e24c0dbd94f2021-04-18T11:14:00ZengNature Publishing GroupNature Communications2041-17232021-04-0112111510.1038/s41467-021-22480-xSOD1 regulates ribosome biogenesis in KRAS mutant non-small cell lung cancerXiaowen Wang0Hong Zhang1Russell Sapio2Jun Yang3Justin Wong4Xin Zhang5Jessie Y. Guo6Sharon Pine7Holly Van Remmen8Hong Li9Eileen White10Chen Liu11Megerditch Kiledjian12Dimitri G. Pestov13X. F. Steven Zheng14Rutgers Cancer Institute of New Jersey, Rutgers, The State University of New JerseyRutgers Cancer Institute of New Jersey, Rutgers, The State University of New JerseyDepartment of Cell Biology and Neuroscience, School of Osteopathic Medicine, Rowan UniversityDepartment of Cell Biology and Neuroscience, Rutgers, The State University of New JerseyRutgers Cancer Institute of New Jersey, Rutgers, The State University of New JerseyRutgers Cancer Institute of New Jersey, Rutgers, The State University of New JerseyRutgers Cancer Institute of New Jersey, Rutgers, The State University of New JerseyRutgers Cancer Institute of New Jersey, Rutgers, The State University of New JerseyAging and Metabolism Program, Oklahoma Medical Research FoundationRutgers Cancer Institute of New Jersey, Rutgers, The State University of New JerseyRutgers Cancer Institute of New Jersey, Rutgers, The State University of New JerseyRutgers Cancer Institute of New Jersey, Rutgers, The State University of New JerseyRutgers Cancer Institute of New Jersey, Rutgers, The State University of New JerseyDepartment of Cell Biology and Neuroscience, School of Osteopathic Medicine, Rowan UniversityRutgers Cancer Institute of New Jersey, Rutgers, The State University of New JerseyThe superoxide dismutase SOD1 is highly expressed in lung cancer but its role has not fully investigated yet. In this study, the authors demonstrate that SOD1 regulates ribosome biogenesis driving KRAS-driven lung tumorigenesis.https://doi.org/10.1038/s41467-021-22480-x
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Xiaowen Wang Hong Zhang Russell Sapio Jun Yang Justin Wong Xin Zhang Jessie Y. Guo Sharon Pine Holly Van Remmen Hong Li Eileen White Chen Liu Megerditch Kiledjian Dimitri G. Pestov X. F. Steven Zheng
spellingShingle	Xiaowen Wang Hong Zhang Russell Sapio Jun Yang Justin Wong Xin Zhang Jessie Y. Guo Sharon Pine Holly Van Remmen Hong Li Eileen White Chen Liu Megerditch Kiledjian Dimitri G. Pestov X. F. Steven Zheng SOD1 regulates ribosome biogenesis in KRAS mutant non-small cell lung cancer Nature Communications
author_facet	Xiaowen Wang Hong Zhang Russell Sapio Jun Yang Justin Wong Xin Zhang Jessie Y. Guo Sharon Pine Holly Van Remmen Hong Li Eileen White Chen Liu Megerditch Kiledjian Dimitri G. Pestov X. F. Steven Zheng
author_sort	Xiaowen Wang
title	SOD1 regulates ribosome biogenesis in KRAS mutant non-small cell lung cancer
title_short	SOD1 regulates ribosome biogenesis in KRAS mutant non-small cell lung cancer
title_full	SOD1 regulates ribosome biogenesis in KRAS mutant non-small cell lung cancer
title_fullStr	SOD1 regulates ribosome biogenesis in KRAS mutant non-small cell lung cancer
title_full_unstemmed	SOD1 regulates ribosome biogenesis in KRAS mutant non-small cell lung cancer
title_sort	sod1 regulates ribosome biogenesis in kras mutant non-small cell lung cancer
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2021-04-01
description	The superoxide dismutase SOD1 is highly expressed in lung cancer but its role has not fully investigated yet. In this study, the authors demonstrate that SOD1 regulates ribosome biogenesis driving KRAS-driven lung tumorigenesis.
url	https://doi.org/10.1038/s41467-021-22480-x
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SOD1 regulates ribosome biogenesis in KRAS mutant non-small cell lung cancer

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