Dextromethorphan Inhibits the Glutamatergic Synaptic Transmission in the Nucleus Tractus Solitarius of Guinea Pigs

Abstract.: Dextromethorphan (DEX) is a widely used non-opioid antitussive. However, the precise site of action and its mechanism were not fully understood. We examined the effects of DEX on AMPA receptor–mediated glutamatergic transmission in the nucleus tractus solitarius (NTS) of guinea pigs. Exci...

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Bibliographic Details
Main Authors: Yoshiaki Ohi, Saori Tsunekawa, Akira Haji
Format: Article
Language:English
Published: Elsevier 2011-01-01
Series:Journal of Pharmacological Sciences
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861319307212