Structural Basis and Evolution of Glycan Receptor Specificities within the Polyomavirus Family

Structural Basis and Evolution of Glycan Receptor Specificities within the Polyomavirus Family

Virus attachment to cell surface receptors is critical for productive infection. In this study, we have used a structure-based approach to investigate the cell surface recognition event for New Jersey polyomavirus (NJPyV) and human polyomavirus 12 (HPyV12). These viruses belong to the polyomavirus f...

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Bibliographic Details
Main Authors: Luisa J. Ströh, Nils H. Rustmeier, Bärbel S. Blaum, Josephine Botsch, Philip Rößler, Florian Wedekink, W. Ian Lipkin, Nischay Mishra, Thilo Stehle
Format: Article
Language:English
Published: American Society for Microbiology 2020-07-01
Series:mBio
Subjects:
polyomavirus
evolution
glycan receptor
host-pathogen interactions
sialic acid
virus tropism
Online Access:https://doi.org/10.1128/mBio.00745-20

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