Long-Term Running Exercise Delays Age-Related Changes in White Matter in Rats

Running exercise, one of the strategies to protect brain function, has positive effects on neurons and synapses in the cortex and hippocampus. However, white matter, as an important structure of the brain, is often overlooked, and the effects of long-term running exercise on white matter are unknown...

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Main Authors: Lin Chen, Feng-lei Chao, Wei Lu, Lei Zhang, Chun-xia Huang, Shu Yang, Xuan Qiu, Hao Yang, Yuan-yu Zhao, San-rong Wang, Chen Li, Yong Tang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Aging Neuroscience
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2020.590530/full
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spelling doaj-10dedb5e023a4db395b8ae13f788ef732020-11-25T03:54:17ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652020-10-011210.3389/fnagi.2020.590530590530Long-Term Running Exercise Delays Age-Related Changes in White Matter in RatsLin Chen0Lin Chen1Feng-lei Chao2Feng-lei Chao3Wei Lu4Wei Lu5Lei Zhang6Lei Zhang7Chun-xia Huang8Shu Yang9Shu Yang10Xuan Qiu11Xuan Qiu12Hao Yang13Hao Yang14Yuan-yu Zhao15Yuan-yu Zhao16San-rong Wang17Chen Li18Yong Tang19Yong Tang20Department of Histology and Embryology, Chongqing Medical University, Chongqing, ChinaAffiliated Brain Hospital of Guangzhou Medical University, Guangzhou Huiai Hospital, Guangzhou, ChinaDepartment of Histology and Embryology, Chongqing Medical University, Chongqing, ChinaLaboratory of Stem Cell and Tissue Engineering, Chongqing Medical University, Chongqing, ChinaDepartment of Histology and Embryology, Chongqing Medical University, Chongqing, ChinaDepartment of Pediatrics, Navy General Hospital, Beijing, ChinaDepartment of Histology and Embryology, Chongqing Medical University, Chongqing, ChinaLaboratory of Stem Cell and Tissue Engineering, Chongqing Medical University, Chongqing, ChinaLaboratory of Stem Cell and Tissue Engineering, Chongqing Medical University, Chongqing, ChinaDepartment of Histology and Embryology, Chongqing Medical University, Chongqing, ChinaDepartment of Histology and Embryology, Capital Medical University, Beijing, ChinaDepartment of Histology and Embryology, Chongqing Medical University, Chongqing, ChinaLaboratory of Stem Cell and Tissue Engineering, Chongqing Medical University, Chongqing, ChinaDepartment of Histology and Embryology, Chongqing Medical University, Chongqing, ChinaLaboratory of Stem Cell and Tissue Engineering, Chongqing Medical University, Chongqing, ChinaDepartment of Histology and Embryology, Chongqing Medical University, Chongqing, ChinaLaboratory of Stem Cell and Tissue Engineering, Chongqing Medical University, Chongqing, ChinaDepartment of Rehabilitation Medicine and Physical Therapy, Second Affiliated Hospital, Chongqing Medical University, Chongqing, ChinaDepartment of Geriatrics Neurology, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaDepartment of Histology and Embryology, Chongqing Medical University, Chongqing, ChinaLaboratory of Stem Cell and Tissue Engineering, Chongqing Medical University, Chongqing, ChinaRunning exercise, one of the strategies to protect brain function, has positive effects on neurons and synapses in the cortex and hippocampus. However, white matter, as an important structure of the brain, is often overlooked, and the effects of long-term running exercise on white matter are unknown. Here, 14-month-old male Sprague–Dawley (SD) rats were divided into a middle-aged control group (18-month-old control group), an old control group (28-month-old control group), and a long-term runner group (28-month-old runner group). The rats in the runner group underwent a 14-month running exercise regime. Spatial learning ability was tested using the Morris water maze, and white matter volume, myelinated fiber parameters, total mature oligodendrocyte number, and white matter capillary parameters were investigated using stereological methods. The levels of growth factors related to nerve growth and vascular growth in peripheral blood and the level of neurite outgrowth inhibitor-A (Nogo-A) in white matter were measured using an enzyme-linked immunosorbent assay (ELISA). The present results indicated that long-term running exercise effectively delayed the age-related decline in spatial learning ability and the atrophy of white matter by protecting against age-related changes in myelinated fibers and oligodendrocytes in the white matter. Moreover, long-term running exercise prevented age-related changes in capillaries within white matter, which might be related to the protective effects of long-term exercise on aged white matter.https://www.frontiersin.org/articles/10.3389/fnagi.2020.590530/fulllong-term running exerciserat white mattermyelinated fibersoligodendrocytescapillaries
collection DOAJ
language English
format Article
sources DOAJ
author Lin Chen
Lin Chen
Feng-lei Chao
Feng-lei Chao
Wei Lu
Wei Lu
Lei Zhang
Lei Zhang
Chun-xia Huang
Shu Yang
Shu Yang
Xuan Qiu
Xuan Qiu
Hao Yang
Hao Yang
Yuan-yu Zhao
Yuan-yu Zhao
San-rong Wang
Chen Li
Yong Tang
Yong Tang
spellingShingle Lin Chen
Lin Chen
Feng-lei Chao
Feng-lei Chao
Wei Lu
Wei Lu
Lei Zhang
Lei Zhang
Chun-xia Huang
Shu Yang
Shu Yang
Xuan Qiu
Xuan Qiu
Hao Yang
Hao Yang
Yuan-yu Zhao
Yuan-yu Zhao
San-rong Wang
Chen Li
Yong Tang
Yong Tang
Long-Term Running Exercise Delays Age-Related Changes in White Matter in Rats
Frontiers in Aging Neuroscience
long-term running exercise
rat white matter
myelinated fibers
oligodendrocytes
capillaries
author_facet Lin Chen
Lin Chen
Feng-lei Chao
Feng-lei Chao
Wei Lu
Wei Lu
Lei Zhang
Lei Zhang
Chun-xia Huang
Shu Yang
Shu Yang
Xuan Qiu
Xuan Qiu
Hao Yang
Hao Yang
Yuan-yu Zhao
Yuan-yu Zhao
San-rong Wang
Chen Li
Yong Tang
Yong Tang
author_sort Lin Chen
title Long-Term Running Exercise Delays Age-Related Changes in White Matter in Rats
title_short Long-Term Running Exercise Delays Age-Related Changes in White Matter in Rats
title_full Long-Term Running Exercise Delays Age-Related Changes in White Matter in Rats
title_fullStr Long-Term Running Exercise Delays Age-Related Changes in White Matter in Rats
title_full_unstemmed Long-Term Running Exercise Delays Age-Related Changes in White Matter in Rats
title_sort long-term running exercise delays age-related changes in white matter in rats
publisher Frontiers Media S.A.
series Frontiers in Aging Neuroscience
issn 1663-4365
publishDate 2020-10-01
description Running exercise, one of the strategies to protect brain function, has positive effects on neurons and synapses in the cortex and hippocampus. However, white matter, as an important structure of the brain, is often overlooked, and the effects of long-term running exercise on white matter are unknown. Here, 14-month-old male Sprague–Dawley (SD) rats were divided into a middle-aged control group (18-month-old control group), an old control group (28-month-old control group), and a long-term runner group (28-month-old runner group). The rats in the runner group underwent a 14-month running exercise regime. Spatial learning ability was tested using the Morris water maze, and white matter volume, myelinated fiber parameters, total mature oligodendrocyte number, and white matter capillary parameters were investigated using stereological methods. The levels of growth factors related to nerve growth and vascular growth in peripheral blood and the level of neurite outgrowth inhibitor-A (Nogo-A) in white matter were measured using an enzyme-linked immunosorbent assay (ELISA). The present results indicated that long-term running exercise effectively delayed the age-related decline in spatial learning ability and the atrophy of white matter by protecting against age-related changes in myelinated fibers and oligodendrocytes in the white matter. Moreover, long-term running exercise prevented age-related changes in capillaries within white matter, which might be related to the protective effects of long-term exercise on aged white matter.
topic long-term running exercise
rat white matter
myelinated fibers
oligodendrocytes
capillaries
url https://www.frontiersin.org/articles/10.3389/fnagi.2020.590530/full
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