Long-Term Running Exercise Delays Age-Related Changes in White Matter in Rats
Running exercise, one of the strategies to protect brain function, has positive effects on neurons and synapses in the cortex and hippocampus. However, white matter, as an important structure of the brain, is often overlooked, and the effects of long-term running exercise on white matter are unknown...
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Frontiers Media S.A.
2020-10-01
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Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2020.590530/full |
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doaj-10dedb5e023a4db395b8ae13f788ef732020-11-25T03:54:17ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652020-10-011210.3389/fnagi.2020.590530590530Long-Term Running Exercise Delays Age-Related Changes in White Matter in RatsLin Chen0Lin Chen1Feng-lei Chao2Feng-lei Chao3Wei Lu4Wei Lu5Lei Zhang6Lei Zhang7Chun-xia Huang8Shu Yang9Shu Yang10Xuan Qiu11Xuan Qiu12Hao Yang13Hao Yang14Yuan-yu Zhao15Yuan-yu Zhao16San-rong Wang17Chen Li18Yong Tang19Yong Tang20Department of Histology and Embryology, Chongqing Medical University, Chongqing, ChinaAffiliated Brain Hospital of Guangzhou Medical University, Guangzhou Huiai Hospital, Guangzhou, ChinaDepartment of Histology and Embryology, Chongqing Medical University, Chongqing, ChinaLaboratory of Stem Cell and Tissue Engineering, Chongqing Medical University, Chongqing, ChinaDepartment of Histology and Embryology, Chongqing Medical University, Chongqing, ChinaDepartment of Pediatrics, Navy General Hospital, Beijing, ChinaDepartment of Histology and Embryology, Chongqing Medical University, Chongqing, ChinaLaboratory of Stem Cell and Tissue Engineering, Chongqing Medical University, Chongqing, ChinaLaboratory of Stem Cell and Tissue Engineering, Chongqing Medical University, Chongqing, ChinaDepartment of Histology and Embryology, Chongqing Medical University, Chongqing, ChinaDepartment of Histology and Embryology, Capital Medical University, Beijing, ChinaDepartment of Histology and Embryology, Chongqing Medical University, Chongqing, ChinaLaboratory of Stem Cell and Tissue Engineering, Chongqing Medical University, Chongqing, ChinaDepartment of Histology and Embryology, Chongqing Medical University, Chongqing, ChinaLaboratory of Stem Cell and Tissue Engineering, Chongqing Medical University, Chongqing, ChinaDepartment of Histology and Embryology, Chongqing Medical University, Chongqing, ChinaLaboratory of Stem Cell and Tissue Engineering, Chongqing Medical University, Chongqing, ChinaDepartment of Rehabilitation Medicine and Physical Therapy, Second Affiliated Hospital, Chongqing Medical University, Chongqing, ChinaDepartment of Geriatrics Neurology, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaDepartment of Histology and Embryology, Chongqing Medical University, Chongqing, ChinaLaboratory of Stem Cell and Tissue Engineering, Chongqing Medical University, Chongqing, ChinaRunning exercise, one of the strategies to protect brain function, has positive effects on neurons and synapses in the cortex and hippocampus. However, white matter, as an important structure of the brain, is often overlooked, and the effects of long-term running exercise on white matter are unknown. Here, 14-month-old male Sprague–Dawley (SD) rats were divided into a middle-aged control group (18-month-old control group), an old control group (28-month-old control group), and a long-term runner group (28-month-old runner group). The rats in the runner group underwent a 14-month running exercise regime. Spatial learning ability was tested using the Morris water maze, and white matter volume, myelinated fiber parameters, total mature oligodendrocyte number, and white matter capillary parameters were investigated using stereological methods. The levels of growth factors related to nerve growth and vascular growth in peripheral blood and the level of neurite outgrowth inhibitor-A (Nogo-A) in white matter were measured using an enzyme-linked immunosorbent assay (ELISA). The present results indicated that long-term running exercise effectively delayed the age-related decline in spatial learning ability and the atrophy of white matter by protecting against age-related changes in myelinated fibers and oligodendrocytes in the white matter. Moreover, long-term running exercise prevented age-related changes in capillaries within white matter, which might be related to the protective effects of long-term exercise on aged white matter.https://www.frontiersin.org/articles/10.3389/fnagi.2020.590530/fulllong-term running exerciserat white mattermyelinated fibersoligodendrocytescapillaries |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Lin Chen Lin Chen Feng-lei Chao Feng-lei Chao Wei Lu Wei Lu Lei Zhang Lei Zhang Chun-xia Huang Shu Yang Shu Yang Xuan Qiu Xuan Qiu Hao Yang Hao Yang Yuan-yu Zhao Yuan-yu Zhao San-rong Wang Chen Li Yong Tang Yong Tang |
spellingShingle |
Lin Chen Lin Chen Feng-lei Chao Feng-lei Chao Wei Lu Wei Lu Lei Zhang Lei Zhang Chun-xia Huang Shu Yang Shu Yang Xuan Qiu Xuan Qiu Hao Yang Hao Yang Yuan-yu Zhao Yuan-yu Zhao San-rong Wang Chen Li Yong Tang Yong Tang Long-Term Running Exercise Delays Age-Related Changes in White Matter in Rats Frontiers in Aging Neuroscience long-term running exercise rat white matter myelinated fibers oligodendrocytes capillaries |
author_facet |
Lin Chen Lin Chen Feng-lei Chao Feng-lei Chao Wei Lu Wei Lu Lei Zhang Lei Zhang Chun-xia Huang Shu Yang Shu Yang Xuan Qiu Xuan Qiu Hao Yang Hao Yang Yuan-yu Zhao Yuan-yu Zhao San-rong Wang Chen Li Yong Tang Yong Tang |
author_sort |
Lin Chen |
title |
Long-Term Running Exercise Delays Age-Related Changes in White Matter in Rats |
title_short |
Long-Term Running Exercise Delays Age-Related Changes in White Matter in Rats |
title_full |
Long-Term Running Exercise Delays Age-Related Changes in White Matter in Rats |
title_fullStr |
Long-Term Running Exercise Delays Age-Related Changes in White Matter in Rats |
title_full_unstemmed |
Long-Term Running Exercise Delays Age-Related Changes in White Matter in Rats |
title_sort |
long-term running exercise delays age-related changes in white matter in rats |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Aging Neuroscience |
issn |
1663-4365 |
publishDate |
2020-10-01 |
description |
Running exercise, one of the strategies to protect brain function, has positive effects on neurons and synapses in the cortex and hippocampus. However, white matter, as an important structure of the brain, is often overlooked, and the effects of long-term running exercise on white matter are unknown. Here, 14-month-old male Sprague–Dawley (SD) rats were divided into a middle-aged control group (18-month-old control group), an old control group (28-month-old control group), and a long-term runner group (28-month-old runner group). The rats in the runner group underwent a 14-month running exercise regime. Spatial learning ability was tested using the Morris water maze, and white matter volume, myelinated fiber parameters, total mature oligodendrocyte number, and white matter capillary parameters were investigated using stereological methods. The levels of growth factors related to nerve growth and vascular growth in peripheral blood and the level of neurite outgrowth inhibitor-A (Nogo-A) in white matter were measured using an enzyme-linked immunosorbent assay (ELISA). The present results indicated that long-term running exercise effectively delayed the age-related decline in spatial learning ability and the atrophy of white matter by protecting against age-related changes in myelinated fibers and oligodendrocytes in the white matter. Moreover, long-term running exercise prevented age-related changes in capillaries within white matter, which might be related to the protective effects of long-term exercise on aged white matter. |
topic |
long-term running exercise rat white matter myelinated fibers oligodendrocytes capillaries |
url |
https://www.frontiersin.org/articles/10.3389/fnagi.2020.590530/full |
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