Pharmacological inhibition of dynamin II reduces constitutive protein secretion from primary human macrophages.

Pharmacological inhibition of dynamin II reduces constitutive protein secretion from primary human macrophages.

Dynamins are fission proteins that mediate endocytic and exocytic membrane events and are pharmacological therapeutic targets. These studies investigate whether dynamin II regulates constitutive protein secretion and show for the first time that pharmacological inhibition of dynamin decreases secret...

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Bibliographic Details
Main Authors: Maaike Kockx, Denuja Karunakaran, Mathew Traini, Jing Xue, Kuan Yen Huang, Diana Nawara, Katharina Gaus, Wendy Jessup, Phillip J Robinson, Leonard Kritharides
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4210248?pdf=render

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