An Acridine-Based Fluorescent Sensor for Monitoring ClO⁻ in Water Samples and Zebrafish

• Main Authors: Su Chan Lee, Soyoung Park, Haeri So, Gyudong Lee, Ki-Tae Kim, Cheal Kim
• Format: Article
• Language: English
• Published: MDPI AG 2020-08-01
• Series: Sensors
• Subjects: acridine; fluorescent chemosensor; hypochlorite; zebrafish; theoretical calculations
• Online Access: https://www.mdpi.com/1424-8220/20/17/4764
• ISSN: 1424-8220

A novel acridine-based fluorescent chemosensor, <b>BK</b> ((E)-2-((acridine-9-ylimino)methyl)-N-benzhydrylhydrazine-1-carbothioamide), for monitoring ClO⁻ was prepared. The sensor <b>BK</b> was synthesized by introducing a new synthetic route of making aldehyde group using formic hydrazide. Probe <b>BK</b> displayed notable fluorescence quenching in the presence of ClO⁻ and showed a great selectivity over other guest analytes. The detection limit was calculated to be 7.65 μM. Additionally, <b>BK</b> was satisfactorily applied for sensing ClO⁻ in water samples and zebrafish.