Conservation patterns of HIV-1 RT connection and RNase H domains: identification of new mutations in NRTI-treated patients.

Conservation patterns of HIV-1 RT connection and RNase H domains: identification of new mutations in NRTI-treated patients.

BACKGROUND: Although extensive HIV drug resistance information is available for the first 400 amino acids of its reverse transcriptase, the impact of antiretroviral treatment in C-terminal domains of Pol (thumb, connection and RNase H) is poorly understood. METHODS AND FINDINGS: We wanted to charact...

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Bibliographic Details
Main Authors: André F A Santos, Renan B Lengruber, Esmeralda A Soares, Abhay Jere, Eduardo Sprinz, Ana M B Martinez, Jussara Silveira, Fernando S Sion, Vinay K Pathak, Marcelo A Soares
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2262134?pdf=render

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