Nrf2-Heme Oxygenase-1 Attenuates High-Glucose-Induced Epithelial-to-Mesenchymal Transition of Renal Tubule Cells by Inhibiting ROS-Mediated PI3K/Akt/GSK-3β Signaling

Nrf2-Heme Oxygenase-1 Attenuates High-Glucose-Induced Epithelial-to-Mesenchymal Transition of Renal Tubule Cells by Inhibiting ROS-Mediated PI3K/Akt/GSK-3β Signaling

Background. Epithelial-to-mesenchymal transition (EMT) is thought to play a significant role in the advancement to chronic kidney disease and contributes to the deposition of extracellular matrix proteins and renal fibrosis relating to diabetic nephropathy. Method. We studied the effect of Nrf2-HO-1...

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Bibliographic Details
Main Authors:	Jong Ho Shin, Kyeong Min Kim, Jin Uk Jeong, Jae Min Shin, Ju Hyung Kang, Kitae Bang, Joo-Heon Kim
Format:	Article
Language:	English
Published:	Hindawi Limited 2019-01-01
Series:	Journal of Diabetes Research
Online Access:	http://dx.doi.org/10.1155/2019/2510105

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