Inhibition of Non-Small Cell Lung Cancer Cells by Oxy210, an Oxysterol-Derivative that Antagonizes TGFβ and Hedgehog Signaling

Inhibition of Non-Small Cell Lung Cancer Cells by Oxy210, an Oxysterol-Derivative that Antagonizes TGFβ and Hedgehog Signaling

Non-Small Cell Lung Cancer (NSCLC) is a common malignancy and leading cause of death by cancer. Metastasis and drug resistance are serious clinical problems encountered in NSCLC therapy. Aberrant activation of the Transforming Growth Factor beta (TGFβ) and Hedgehog (Hh) signal transduction...

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Bibliographic Details
Main Authors: Frank Stappenbeck, Feng Wang, Liu-Ya Tang, Ying E. Zhang, Farhad Parhami
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:Cells
Subjects:
tgfβ signaling
hedgehog signaling
oxysterols
metastasis
drug resistance
Online Access:https://www.mdpi.com/2073-4409/8/10/1297

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