Mass balance and pharmacokinetics of an oral dose of 14C‐napabucasin in healthy adult male subjects

Mass balance and pharmacokinetics of an oral dose of 14C‐napabucasin in healthy adult male subjects

Abstract This phase 1, open‐label study assessed14C‐napabucasin absorption, metabolism, and excretion, napabucasin pharmacokinetics, and napabucasin metabolites (primary objectives); safety/tolerability were also evaluated. Eight healthy males (18–45 years) received a single oral 240‐mg napabucasin...

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Bibliographic Details
Main Authors: Xiaoshu Dai, Michael D. Karol, Matthew Hitron, Marjie L. Hard, John Evan Blanchard, Nicola C. J. E. Eraut, Natalie Rich, Brandon T. Gufford
Format: Article
Language:English
Published: Wiley 2021-02-01
Series:Pharmacology Research & Perspectives
Subjects:
administration
oral
clinical trial
phase I
drugs
investigational
Online Access:https://doi.org/10.1002/prp2.722

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