Comparison of efficiency of intravitreal ceftazidime and intravitreal cefepime in the treatment of experimental Pseudomonas aeruginosa endophthalmitis

• Main Authors: Nurettin Deniz, Orhan Aydemir, Mete Güler, Nusret Akpolat, Ahmet Kizirgil
• Format: Article
• Language: English
• Published: Wolters Kluwer Medknow Publications 2013-01-01
• Series: Indian Journal of Ophthalmology
• Subjects: Chemotherapy; focal treatment; retinoblastoma; Allergic eye disease; papillae; shield ulcer; vernal keratoconjunctivitis; Anti-VEGF injections; bevacizumab; neovascular age-related macular degeneration; ranibizumab; submacular hemorrhage; Emergency department; ocular; trauma; work related injuries; Ocular trauma; open globe injury; preoperative (initial) visual acuity; prognostic factors; relative afferent pupillary defect; Configuration; choroidal neovascular membrane; foveal slope; foveal thickness; macular pigment; Descemet membrane; keratoplasty; optical coherence tomography; Central serous chorioretinopathy; epidural steroid; retinal pigment epithelium detachment; retinal pigment epithelium tear; Self-inflicted; ocular injury; needle; Anterior chamber maintainer; best corrected visual acuity; neodymium yttrium aluminium garnet laser; ocular visco-surgical device; posterior capsule opacification; AIDS; Candida albicans; reverse masquerade syndrome; Bevacizumab; complications; intravitreal injection; Scytalidium sp.; Cefepime; ceftazidime; endophthalmitis; Pseudomonas aeruginosa
• Online Access: http://www.ijo.in/article.asp?issn=0301-4738;year=2013;volume=61;issue=9;spage=525;epage=527;aulast=Deniz

In this study, we evaluated the efficiency of cefepime in the treatment of experimental Pseudomonas aeruginosa endophthalmitis. We compared the findings with the standard dose of ceftazidime (1 mg/0.1 ml). Thirty-six New-Zealand White rabbits were divided into 6 equal groups and were treated with different methods (Group 1 = sham, Group 2 = 0.5 mg/0.1 ml cefepime, Group 3 = 1 mg/0.1 ml cefepime, Group 4 = 2 mg/0.1 ml cefepime, Group 5 = 1 mg/0.1 ml ceftazidime, Group 6 = control). The eyes of rabbits in each group were examined clinically on 1 st , 3 rd , and 6 th day of the experiment. At 6 th day, 0.1 ml vitreous humor aspirates were obtained and plated for quantification on the blood agar and the results were expressed as colony-forming unit/ml. Subsequently, the eyeballs were enucleated and the histopathological evaluation was performed. Our findings denoted beneficial effects of cefepime in treatment groups (especially, in Groups 3 and 4). Intravitreal cefepime may be an alternative drug in the treatment of P. aeruginosa endophthalmitis.