Is a Pacific Coexistence Between Virus and Host the Unexploited Path That May Lead to an HIV Functional Cure?
The SupT1 cell line supports optimal HIV-1 replication, and prolonged in vitro replication in SupT1 cells renders the virus significantly less virulent. This raises the question of whether the infusion of SupT1 cells could be used as a cell-based therapy to induce a pacific coexistence between the H...
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MDPI AG
2013-02-01
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| Series: | Viruses |
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| Online Access: | http://www.mdpi.com/1999-4915/5/2/753 |
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doaj-10a6589405e04cca970988702ec047ca2020-11-25T02:25:40ZengMDPI AGViruses1999-49152013-02-015275375710.3390/v5020753Is a Pacific Coexistence Between Virus and Host the Unexploited Path That May Lead to an HIV Functional Cure?Jonathan FiorThe SupT1 cell line supports optimal HIV-1 replication, and prolonged in vitro replication in SupT1 cells renders the virus significantly less virulent. This raises the question of whether the infusion of SupT1 cells could be used as a cell-based therapy to induce a pacific coexistence between the HIV virus and its human host. In a recent study, I investigated this potential therapeutic strategy in vitro. The results suggested that this approach should be further explored in HIV-susceptible animal models. Such studies may lead to the development of a functional cure for HIV infection.http://www.mdpi.com/1999-4915/5/2/753HIV infectionFunctional cureCell-based therapyVifAPOBEC3GSupT1 cellsHIV reservoirCD4+ T cells |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Jonathan Fior |
| spellingShingle |
Jonathan Fior Is a Pacific Coexistence Between Virus and Host the Unexploited Path That May Lead to an HIV Functional Cure? Viruses HIV infection Functional cure Cell-based therapy Vif APOBEC3G SupT1 cells HIV reservoir CD4+ T cells |
| author_facet |
Jonathan Fior |
| author_sort |
Jonathan Fior |
| title |
Is a Pacific Coexistence Between Virus and Host the Unexploited Path That May Lead to an HIV Functional Cure? |
| title_short |
Is a Pacific Coexistence Between Virus and Host the Unexploited Path That May Lead to an HIV Functional Cure? |
| title_full |
Is a Pacific Coexistence Between Virus and Host the Unexploited Path That May Lead to an HIV Functional Cure? |
| title_fullStr |
Is a Pacific Coexistence Between Virus and Host the Unexploited Path That May Lead to an HIV Functional Cure? |
| title_full_unstemmed |
Is a Pacific Coexistence Between Virus and Host the Unexploited Path That May Lead to an HIV Functional Cure? |
| title_sort |
is a pacific coexistence between virus and host the unexploited path that may lead to an hiv functional cure? |
| publisher |
MDPI AG |
| series |
Viruses |
| issn |
1999-4915 |
| publishDate |
2013-02-01 |
| description |
The SupT1 cell line supports optimal HIV-1 replication, and prolonged in vitro replication in SupT1 cells renders the virus significantly less virulent. This raises the question of whether the infusion of SupT1 cells could be used as a cell-based therapy to induce a pacific coexistence between the HIV virus and its human host. In a recent study, I investigated this potential therapeutic strategy in vitro. The results suggested that this approach should be further explored in HIV-susceptible animal models. Such studies may lead to the development of a functional cure for HIV infection. |
| topic |
HIV infection Functional cure Cell-based therapy Vif APOBEC3G SupT1 cells HIV reservoir CD4+ T cells |
| url |
http://www.mdpi.com/1999-4915/5/2/753 |
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