Peptide Based Inhibitors of Protein Binding to the Mitogen-Activated Protein Kinase Docking Groove

Peptide Based Inhibitors of Protein Binding to the Mitogen-Activated Protein Kinase Docking Groove

Mitogen-activated protein kinases (MAPK) are important regulatory units in cells and they take part in the regulation of many cellular functions such as cell division, differentiation or apoptosis. All MAPKs have a shallow docking groove that interacts with linear binding motifs of their substrate p...

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Bibliographic Details
Main Authors: Anita Alexa, Orsolya Ember, Ildikó Szabó, Yousef Mo’ath, Ádám L. Póti, Attila Reményi, Zoltán Bánóczi
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Molecular Biosciences
Subjects:
mitogen-activated protein kinase
protein–protein interaction
peptide inhibitor
cellular uptake
cell-penetrating peptide
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2021.690429/full

Internet

https://www.frontiersin.org/articles/10.3389/fmolb.2021.690429/full

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