Characterization of the molecular determinants of primary HIV-1 Vpr proteins: impact of the Q65R and R77Q substitutions on Vpr functions.

Characterization of the molecular determinants of primary HIV-1 Vpr proteins: impact of the Q65R and R77Q substitutions on Vpr functions.

Although HIV-1 Vpr displays several functions in vitro, limited information exists concerning their relevance during infection. Here, we characterized Vpr variants isolated from a rapid and a long-term non-progressor (LTNP). Interestingly, vpr alleles isolated from longitudinal samples of the LTNP r...

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Main Authors: Guillaume Jacquot, Erwann Le Rouzic, Priscilla Maidou-Peindara, Marion Maizy, Jean-Jacques Lefrère, Vincent Daneluzzi, Carlos M R Monteiro-Filho, Duanping Hong, Vicente Planelles, Laurence Morand-Joubert, Serge Benichou
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-10-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2759284?pdf=render

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