Synthesis of α-Aminophosphonic Acid Derivatives Through the Addition of <i>O</i>- and <i>S</i>-Nucleophiles to 2<i>H</i>-Azirines and Their Antiproliferative Effect on A549 Human Lung Adenocarcinoma Cells

Synthesis of α-Aminophosphonic Acid Derivatives Through the Addition of <i>O</i>- and <i>S</i>-Nucleophiles to 2<i>H</i>-Azirines and Their Antiproliferative Effect on A549 Human Lung Adenocarcinoma Cells

This work reports a straightforward regioselective synthetic methodology to prepare α-aminophosphine oxides and phosphonates through the addition of oxygen and sulfur nucleophiles to the C–N double bond of 2<i>H</i>-azirine derivatives. Determined by the nature of the nucleophile, differ...

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Bibliographic Details
Main Authors: Victor Carramiñana, Ana M. Ochoa de Retana, Francisco Palacios, Jesús M. de los Santos
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Molecules
Subjects:
allylic α-aminophosphorus compounds
α-aminophosphine oxide or phosphonate acetals
antiproliferative effect
aziridines
2<i>H</i>-azirines
Online Access:https://www.mdpi.com/1420-3049/25/15/3332

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