Elevating Insulin Signaling Using a Constitutively Active Insulin Receptor Increases Glucose Metabolism and Expression of GLUT3 in Hippocampal Neurons

Elevating Insulin Signaling Using a Constitutively Active Insulin Receptor Increases Glucose Metabolism and Expression of GLUT3 in Hippocampal Neurons

Insulin signaling is an integral component of healthy brain function, with evidence of positive insulin-mediated alterations in synaptic integrity, cerebral blood flow, inflammation, and memory. However, the specific pathways targeted by this peptide remain unclear. Previously, our lab used a molecu...

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Bibliographic Details
Main Authors: Hilaree N. Frazier, Adam O. Ghoweri, Katie L. Anderson, Ruei-Lung Lin, Gabriel J. Popa, Michael D. Mendenhall, Lawrence P. Reagan, Rolf J. Craven, Olivier Thibault
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Neuroscience
Subjects:
hippocampus
neuron
astrocyte
glucose metabolism
GLUT3
signaling
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2020.00668/full

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