The effect of lipocortin 1 on neutrophil deformability

The effect of lipocortin 1 on neutrophil deformability

Lipocortn 1 (Lc1) is an anti-inflammatory protein, which, given systemically, inhibits polymorphonuclear neutrophil (PMN) emigration from the circulation to sites of inflammation; delivery of Lc1 to the inflamed site is ineffective. We have examined the effect of Lc1 on changes in PMN deformability,...

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Main Authors: E. M. Drost, W. MacNee, S. F. Smith
Format: Article
Language:English
Published: Hindawi Limited 1996-01-01
Series:Mediators of Inflammation
Online Access:http://dx.doi.org/10.1155/S0962935196000257
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spelling doaj-108dcbf0dffd42908cb9baa40e6e0b762020-11-25T00:29:26ZengHindawi LimitedMediators of Inflammation0962-93511466-18611996-01-015318819010.1155/S0962935196000257The effect of lipocortin 1 on neutrophil deformabilityE. M. Drost0W. MacNee1S. F. Smith2Department of Medicine, Rayne Laboratory, University of Edinburgh, Medical School, Teviot Place, Edinburgh EH8 9AG, UKDepartment of Medicine, Rayne Laboratory, University of Edinburgh, Medical School, Teviot Place, Edinburgh EH8 9AG, UKDepartment of Medicine, Charing Cross and Westminster Medical School, Fulham Palace Road, London W6 8RF, UKLipocortn 1 (Lc1) is an anti-inflammatory protein, which, given systemically, inhibits polymorphonuclear neutrophil (PMN) emigration from the circulation to sites of inflammation; delivery of Lc1 to the inflamed site is ineffective. We have examined the effect of Lc1 on changes in PMN deformability, and observed a consistent improvement in the deformability of unstimulated PMN; N-formyl-methionyl-leucyl-phenylalanine (fMLP)-activated cell deformability was unaltered. A Lc1-induced increase in cell deformability may reduce PMN sequestration so contributing to the anti-migratory effects of systemic Lc1 previously demonstrated in vivo.http://dx.doi.org/10.1155/S0962935196000257
collection DOAJ
language English
format Article
sources DOAJ
author E. M. Drost
W. MacNee
S. F. Smith
spellingShingle E. M. Drost
W. MacNee
S. F. Smith
The effect of lipocortin 1 on neutrophil deformability
Mediators of Inflammation
author_facet E. M. Drost
W. MacNee
S. F. Smith
author_sort E. M. Drost
title The effect of lipocortin 1 on neutrophil deformability
title_short The effect of lipocortin 1 on neutrophil deformability
title_full The effect of lipocortin 1 on neutrophil deformability
title_fullStr The effect of lipocortin 1 on neutrophil deformability
title_full_unstemmed The effect of lipocortin 1 on neutrophil deformability
title_sort effect of lipocortin 1 on neutrophil deformability
publisher Hindawi Limited
series Mediators of Inflammation
issn 0962-9351
1466-1861
publishDate 1996-01-01
description Lipocortn 1 (Lc1) is an anti-inflammatory protein, which, given systemically, inhibits polymorphonuclear neutrophil (PMN) emigration from the circulation to sites of inflammation; delivery of Lc1 to the inflamed site is ineffective. We have examined the effect of Lc1 on changes in PMN deformability, and observed a consistent improvement in the deformability of unstimulated PMN; N-formyl-methionyl-leucyl-phenylalanine (fMLP)-activated cell deformability was unaltered. A Lc1-induced increase in cell deformability may reduce PMN sequestration so contributing to the anti-migratory effects of systemic Lc1 previously demonstrated in vivo.
url http://dx.doi.org/10.1155/S0962935196000257
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