Paracellular Pathway Enhancement of Metformin Hydrochloride via Molecular Dispersion in Span 60 Microparticles

Paracellular Pathway Enhancement of Metformin Hydrochloride via Molecular Dispersion in Span 60 Microparticles

Surfactants are well known as permeation enhancers. Span 60 microparticles encapsulating different concentrations of metformin HCl were prepared by using rapid congeal melting technique. Electro-scanning microscope showed smooth surface but less round microparticles. The actual drug content was near...

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Bibliographic Details
Main Authors: Omar Y. Mady, Ahmed A. Donia, Adam A. Al-Shoubki, Waseem Qasim
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-07-01
Series:Frontiers in Pharmacology
Subjects:
Span 60 metformin HCl
melt congealing technique
total permeability percentage
paracellular pathway
non-everted sac
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.00713/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.00713/full

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