Potent antiproliferative cembrenoids accumulate in tobacco upon infection with Rhodococcus fascians and trigger unusual microtubule dynamics in human glioblastoma cells.

Potent antiproliferative cembrenoids accumulate in tobacco upon infection with Rhodococcus fascians and trigger unusual microtubule dynamics in human glioblastoma cells.

AIMS: Though plant metabolic changes are known to occur during interactions with bacteria, these were rarely challenged for pharmacologically active compounds suitable for further drug development. Here, the occurrence of specific chemicals with antiproliferative activity against human cancer cell l...

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Bibliographic Details
Main Authors: Aminata P Nacoulma, Veronique Megalizzi, Laurent R Pottier, Manuela De Lorenzi, Sylviane Thoret, Joëlle Dubois, Olivier M Vandeputte, Pierre Duez, Danny Vereecke, Mondher El Jaziri
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3805576?pdf=render

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