Regulation of the Human Papillomavirus Lifecyle through Post-Translational Modifications of the Viral E2 Protein

Regulation of the Human Papillomavirus Lifecyle through Post-Translational Modifications of the Viral E2 Protein

The human papillomavirus (HPV) is a DNA tumor virus that infects cutaneous and mucosal epithelia where high-risk (HR) HPV infections lead to cervical, oropharyngeal, and anogenital cancers. Worldwide, nearly 5% of all cancers are caused by HR HPV. The viral E2 protein is essential for episomal repli...

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Bibliographic Details
Main Authors: Leny Jose, Timra Gilson, Elliot J. Androphy, Marsha DeSmet
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Pathogens
Subjects:
HPV E2
replication
PTM
Online Access:https://www.mdpi.com/2076-0817/10/7/793
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spelling doaj-1083e4ab0ce94f2f83d2386d550a096c2021-07-23T13:59:22ZengMDPI AGPathogens2076-08172021-06-011079379310.3390/pathogens10070793Regulation of the Human Papillomavirus Lifecyle through Post-Translational Modifications of the Viral E2 ProteinLeny Jose0Timra Gilson1Elliot J. Androphy2Marsha DeSmet3Department of Dermatology, Indiana University School of Medicine, Indianapolis, IN 46202, USADepartment of Dermatology, Indiana University School of Medicine, Indianapolis, IN 46202, USADepartment of Dermatology, Indiana University School of Medicine, Indianapolis, IN 46202, USADepartment of Dermatology, Indiana University School of Medicine, Indianapolis, IN 46202, USAThe human papillomavirus (HPV) is a DNA tumor virus that infects cutaneous and mucosal epithelia where high-risk (HR) HPV infections lead to cervical, oropharyngeal, and anogenital cancers. Worldwide, nearly 5% of all cancers are caused by HR HPV. The viral E2 protein is essential for episomal replication throughout the viral lifecycle. The E2 protein is regulated by phosphorylation, acetylation, sumoylation, and ubiquitination. In this mini-review, we summarize the recent advancements made to identify post translational modifications within E2 and their ability to control viral replication.https://www.mdpi.com/2076-0817/10/7/793HPV E2replicationPTM
collection DOAJ
language English
format Article
sources DOAJ
author Leny Jose
Timra Gilson
Elliot J. Androphy
Marsha DeSmet
spellingShingle Leny Jose
Timra Gilson
Elliot J. Androphy
Marsha DeSmet
Regulation of the Human Papillomavirus Lifecyle through Post-Translational Modifications of the Viral E2 Protein
Pathogens
HPV E2
replication
PTM
author_facet Leny Jose
Timra Gilson
Elliot J. Androphy
Marsha DeSmet
author_sort Leny Jose
title Regulation of the Human Papillomavirus Lifecyle through Post-Translational Modifications of the Viral E2 Protein
title_short Regulation of the Human Papillomavirus Lifecyle through Post-Translational Modifications of the Viral E2 Protein
title_full Regulation of the Human Papillomavirus Lifecyle through Post-Translational Modifications of the Viral E2 Protein
title_fullStr Regulation of the Human Papillomavirus Lifecyle through Post-Translational Modifications of the Viral E2 Protein
title_full_unstemmed Regulation of the Human Papillomavirus Lifecyle through Post-Translational Modifications of the Viral E2 Protein
title_sort regulation of the human papillomavirus lifecyle through post-translational modifications of the viral e2 protein
publisher MDPI AG
series Pathogens
issn 2076-0817
publishDate 2021-06-01
description The human papillomavirus (HPV) is a DNA tumor virus that infects cutaneous and mucosal epithelia where high-risk (HR) HPV infections lead to cervical, oropharyngeal, and anogenital cancers. Worldwide, nearly 5% of all cancers are caused by HR HPV. The viral E2 protein is essential for episomal replication throughout the viral lifecycle. The E2 protein is regulated by phosphorylation, acetylation, sumoylation, and ubiquitination. In this mini-review, we summarize the recent advancements made to identify post translational modifications within E2 and their ability to control viral replication.
topic HPV E2
replication
PTM
url https://www.mdpi.com/2076-0817/10/7/793
work_keys_str_mv AT lenyjose regulationofthehumanpapillomaviruslifecylethroughposttranslationalmodificationsofthevirale2protein
AT timragilson regulationofthehumanpapillomaviruslifecylethroughposttranslationalmodificationsofthevirale2protein
AT elliotjandrophy regulationofthehumanpapillomaviruslifecylethroughposttranslationalmodificationsofthevirale2protein
AT marshadesmet regulationofthehumanpapillomaviruslifecylethroughposttranslationalmodificationsofthevirale2protein
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